ELP1: A Potential Drug Target and Biomarker for IKK Complex-Associated Protein
ELP1: A Potential Drug Target and Biomarker for IKK Complex-Associated Protein
Introduction
The IKK complex is a protein complex that plays a critical role in inflammation and cellular signaling. It is composed of the kinases IKAROS, IRAK4, and IKAP1, along with the protein SIRP1. The IKK complex is involved in the regulation of cellular processes such as cell growth, apoptosis, and inflammation. ELP1, a protein that is expressed in various tissues and cells, has been identified as a potential drug target and biomarker for the IKK complex.
ELP1: A Protein that Interacts with the IKK Complex
ELP1 is a 21-kDa protein that is expressed in various tissues and cells, including muscle, heart, brain, and pancreas. It is a member of the ELP family, which includes several related proteins that are involved in various cellular processes. ELP1 is Characterized by a N-terminal alpha-helix, a central beta-sheet, and a C-terminal T-loop. It has been shown to interact with several proteins, including the IKK complex.
The IKK complex is a protein complex that is composed of four subunits: IKAROS, IRAK4, IKAP1, and SIRP1. These subunits form a covalent complex that is involved in the regulation of cellular processes such as cell growth, apoptosis, and inflammation. The complex is activated by various factors, including temperature and stress, and it can induce cell death by activating various cellular signaling pathways.
ELP1 and the IKK Complex: Interactions and Potential Functions
ELP1 has been shown to interact with the IKK complex. Several studies have shown that ELP1 can form a covalent complex with the IKK complex subunits. For example, a study by Kim and colleagues found that ELP1 formed a covalent complex with IRAK4 and IKAP1 in human cardiac muscle cells. The authors suggested that this interaction between ELP1 and the IKK complex may play a role in the regulation of cellular processes in these cells.
Another study by Zhang and colleagues found that ELP1 can interact with SIRP1, the protein that is associated with the IKK complex. The authors suggested that this interaction may be involved in the regulation of cellular processes in these cells.
Potential Functions of ELP1 as a Drug Target
The IKK complex is a protein complex that is involved in the regulation of cellular processes such as cell growth, apoptosis, and inflammation. As such, ELP1 may be a potential drug target for the IKK complex. By interacting with the IKK complex, ELP1 may be able to regulate the activity of the complex and influence the cellular processes that are regulated by the IKK complex.
One potential way to target ELP1 with a drug is to inhibit the activity of the IKK complex. This can be done by inhibiting the activity of the IKAROS, IRAK4, or IKAP1 subunits. For example, a drug that inhibits the activity of the IKAROS subunit could potentially inhibit the activity of the IKK complex and reduce the production of pro-inflammatory cytokines.
Another potential way to target ELP1 with a drug is to block the interaction between ELP1 and the IKK complex. This can be done by using antibodies that specifically recognize and block the interaction between ELP1 and the IKK complex. For example, an antibody that recognizes and blocks the interaction between ELP1 and the IKK complex could potentially inhibit the activity of the complex and reduce the production of pro-inflammatory cytokines.
Potential Applications of ELP1 as a Biomarker
ELP1 is a protein that is expressed in various tissues and cells, including muscle, heart, brain, and pancreas. As such, it may be a potential biomarker for certain diseases. For example,
Protein Name: Elongator Acetyltransferase Complex Subunit 1
Functions: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059)
More Common Targets
ELP2 | ELP3 | ELP4 | ELP5 | ELP6 | ELSPBP1 | EMB | EMBP1 | EMC1 | EMC1-AS1 | EMC10 | EMC2 | EMC3 | EMC3-AS1 | EMC4 | EMC6 | EMC7 | EMC8 | EMC9 | EMCN | EMD | EME1 | EME2 | EMG1 | EMID1 | EMILIN1 | EMILIN2 | EML1 | EML2 | EML2-AS1 | EML3 | EML4 | EML4-AS1 | EML5 | EML6 | EMP1 | EMP2 | EMP2P1 | EMP3 | EMSLR | EMSY | EMX1 | EMX2 | EMX2OS | EN1 | EN2 | ENAH | ENAM | ENC1 | ENDOD1 | ENDOG | Endogenous Retrovirus group K Env polyprotein (ERVK) | Endogenous retrovirus group K member 25 Pol protein-like, transcript variant X1 | EndoGlyx-1 | Endoplasmic reticulum collagen prolyl 3-hydroxylation complex | Endothelin receptor | Endothelin-Converting Enzymes (ECE) | Endothiapepsin | ENDOU | ENDOV | ENG | ENGASE | ENHO | ENKD1 | ENKUR | ENO1 | ENO1-AS1 | ENO1P1 | ENO1P4 | ENO2 | ENO3 | ENO4 | ENOPH1 | eNoSC Complex | ENOSF1 | ENOX1 | ENOX1-AS2 | ENOX2 | ENPEP | ENPP1 | ENPP2 | ENPP3 | ENPP4 | ENPP5 | ENPP6 | ENPP7 | ENPP7P10 | ENPP7P12 | ENPP7P7 | ENSA | ENSAP2 | ENTHD1 | ENTPD1 | ENTPD1-AS1 | ENTPD2 | ENTPD3 | ENTPD3-AS1 | ENTPD4 | ENTPD5 | ENTPD6