ENPP3: A Protein with A Wide Range of Functions (G5169)

Target Name: ENPP3

NCBI ID: G5169

ENPP3: A Protein with A Wide Range of Functions

ENPP3 (ENP-3) is a protein that is expressed in various tissues throughout the body. It is a key regulator of cell signaling pathways and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of ENPP3 is its role in the regulation of angiogenesis, the process by which new blood vessels are formed. ENPP3 has been shown to play a negative role in the development of angiogenesis, by inhibiting the formation of new blood vessels.

This is important because many diseases are characterized by the buildup of excess blood vessels, such as in cancer, where new blood vessels can serve as a source of tumor growth. By inhibiting the formation of new blood vessels, ENPP3 may have the potential to be a drug target or biomarker for these diseases.

Another function of ENPP3 is its role in the regulation of cell signaling pathways. ENPP3 has been shown to play a positive role in the regulation of cell signaling pathways, by activating the MAPK/ERK signaling pathway. This pathway is important for a wide range of cellular processes, including cell growth, differentiation, and survival.

The MAPK/ERK signaling pathway is a well-established target for many drugs, including those used to treat cancer. By activating this pathway, ENPP3 may have the potential to be a drug target for cancer, by inhibiting the growth and survival of cancer cells.

In addition to its role in cell signaling pathways, ENPP3 is also involved in the regulation of inflammation. ENPP3 has been shown to play a negative role in the regulation of inflammation, by inhibiting the production of pro-inflammatory cytokines.

This is important because many diseases are characterized by the presence of inflammation, such as in autoimmune disorders. By inhibiting the production of pro-inflammatory cytokines, ENPP3 may have the potential to be a drug target or biomarker for these diseases.

Overall, ENPP3 is a protein that has a wide range of functions, including its role in cell signaling pathways, angiogenesis, and inflammation. As a result, it may be a promising drug target or biomarker for a wide range of diseases.

Protein Name: Ectonucleotide Pyrophosphatase/phosphodiesterase 3

Functions: Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has also alkaline phosphodiesterase activity (PubMed:11342463)

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