EPHA1: A Potential Drug Target and Biomarker (G2041)

Target Name: EPHA1

NCBI ID: G2041

EPHA1: A Potential Drug Target and Biomarker

EPHA1 (Epidaudin-1) is a protein that is expressed in various tissues throughout the body, including the skin, hair, and nails. It is a member of the cadherin family, which is a group of transmembrane proteins that play a crucial role in cell-cell adhesion.

One of the unique features of EPHA1 is its ability to interact with cadherins on the surface of cancer cells. This interaction allows EPHA1 to act as a drug target, as well as a biomarker, in the treatment of various diseases.

EPHA1 has been shown to be involved in a number of different processes in the development and progression of cancer. For example, studies have shown that EPHA1 is involved in the regulation of cell growth, angiogenesis, and the immune response.

In addition to its role in cancer, EPHA1 has also been shown to be involved in a number of other biological processes that are important for human health. For example, it is involved in the development and maintenance of the skin and hair, and is thought to play a role in the regulation of inflammation.

Given its involvement in so many different processes, it is not surprising that EPHA1 has been identified as a potential drug target. Researchers are currently working to develop small molecules and other compounds that can inhibit the activity of EPHA1 and prevent it from interacting with cadherins on cancer cells.

These compounds have the potential to be used in a variety of different treatments, including cancer, skin and nail disorders, and other conditions that are characterized by the buildup of excessive cell growth or inflammation.

In conclusion, EPHA1 is a protein that has the potential to be a drug target and biomarker for a variety of different diseases. As research continues to advance, it is likely that the full range of its functions and potential uses will become clearer.

Protein Name: EPH Receptor A1

Functions: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis

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