ENTPD1: The Potential Drug Target for Ectonucleoside Triphosphate Diphosphohydrolase 1

Target Name: ENTPD1

NCBI ID: G953

ENTPD1: The Potential Drug Target for Ectonucleoside Triphosphate Diphosphohydrolase 1

Introduction

Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) is an enzyme involved in the repair of DNA damage in the cell. It is a critical enzyme for the maintenance of DNA homeostasis and plays a crucial role in preventing genetic disorders caused by DNA damage. ENTPD1 is also a potential drug target for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The Importance of ENTPD1

ENTPD1 is an enzyme that is expressed in most tissues of the body and is involved in the repair of DNA damage. It is a critical enzyme for the maintenance of DNA homeostasis, as it helps to prevent genetic disorders caused by DNA damage. ENTPD1 is also involved in the regulation of cellular processes that are essential for cell survival, such as cell division, apoptosis, and inflammation.

ENTPD1 is a protein that consists of 115 amino acids and has a calculated molecular mass of 13.4 kDa. It is a monomer and has a single transmembrane domain. ENTPD1 is highly conserved, with only one missense mutation having been reported. The encoded protein has a distinct N-terminal region that contains a nucleotide-binding oligomerization domain (NBO), a conserved nucleotide-binding motif (NBM), and a carboxylic acid terminal domain (CAT).

ENTPD1 is involved in the repair of DNA damage by participating in the alternative G-repair repair pathway (APR). The APR is a complex repair pathway that involves the recruitment of several proteins, including ENTPD1. ENTPD1 is involved in the recruitment of repair factors to the site of DNA damage and in the initiation of DNA repair.

ENTPD1 is also involved in the regulation of cellular processes that are essential for cell survival, such as cell division, apoptosis, and inflammation. It is a positive regulator of cell division and has been shown to promote the growth and survival of cancer cells. ENTPD1 is also involved in the regulation of apoptosis, as it has been shown to play a role in the execution of programmed cell death.

ENTPD1 as a Drug Target

The potential use of ENTPD1 as a drug target is due to its involvement in the repair of DNA damage and its association with several diseases. ENTPD1 has been shown to be overexpressed in several types of cancer, including breast, ovarian, and colorectal cancer. It is also overexpressed in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

ENTPD1 has been shown to be involved in the development and progression of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. It is also involved in the regulation of inflammation, as it has been shown to play a role in the regulation of T-cell responses.

ENTPD1 has also been shown to be involved in the regulation of cellular processes that are essential for cell survival, such as cell division, apoptosis, and inflammation. It is a positive regulator of cell division and has been shown to promote the growth and survival of cancer cells. ENTPD1 is also involved in the regulation of apoptosis, as it has been shown to play a role in the execution of programmed cell death.

ENTPD1 as a Potential Drug Target

The potential use of ENTPD1 as a drug target is due to its involvement in the repair of DNA damage and its association with several diseases. ENTPD1 has been shown to be overexpressed in several types of cancer, including breast, ovarian, and colorectal cancer. It is also overexpressed in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

ENTPD1 has also been shown to be involved in the development and progression of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. It is also involved in the regulation of inflammation, as it has been shown to play a role in the regulation of T

Protein Name: Ectonucleoside Triphosphate Diphosphohydrolase 1

Functions: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well

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