ENTR1: A Drug Target and Biomarker for Endosomal Trafficking (G10807)

Target Name: ENTR1

NCBI ID: G10807

ENTR1: A Drug Target and Biomarker for Endosomal Trafficking

Endosomes are a type of organelles that transport and deliver various macromolecules within the cell. They play a crucial role in intracellular signaling, protein delivery, and the regulation of cellular processes. ENTR1, a member of the Kinesin-67 gene family, is a non -coding RNA molecule that is expressed in various tissues and cells. It is known to function as an endosomal associated regulator (EATTR) and is involved in the regulation of endosomal trafficking traffic and the delivery of proteins to the endoplasmic reticulum (ER).

The ENTR1 gene has four splice variants, which result in different transcript variants. Among them, transcript variant 1 (TRANSP-1) is the most abundant and widely expressed transcript, accounting for up to 70% of the total expressed RNA transcripts. TRANSP-1 encodes a protein with 129 amino acid residues, which is predominantly composed of a protein kinase domain, a GFP-like fluorescent protein, and a C-terminal hypervariable region (HVR). The protein is involved in the regulation of endosomal traffic, which is a complex process that involves the delivery of proteins to the ER via the endosomal system.

Endosomal system is a series of organelles that emerge from the ER and end up in various cellular compartments, including the cytosol, the endoplasmic reticulum, and the cell surface. It is a highly specialized system that is responsible for the delivery of proteins to the correct destination and for the regulation of the cell's signaling pathways. The endosomal system is composed of several different components, including the endosomal membrane, the endosomal matrix, and the various enzymes involved in the delivery process.

ENTR1 is one of the key proteins involved in the regulation of endosomal traffic. It is a critical regulator of the endosomal traffic from the ER to the cytosol and is involved in the regulation of the delivery of proteins to the ER. ENTR1 has been shown to play a role in the regulation of various cellular processes, including cell signaling, cell division, and cellular stress.

In addition to its role in the regulation of endosomal traffic, ENTR1 has also been shown to be involved in the regulation of various signaling pathways. It is a key regulator of the PI3K/Akt signaling pathway, which is involved in the regulation of cellular signaling pathways that are critical for the survival and growth of cells. ENTR1 has also been shown to be involved in the regulation of the TGF-β signaling pathway, which is involved in the regulation of cell growth, differentiation, and survival.

ENTR1 is also a potential drug target and biomarker for various diseases. Its involvement in the regulation of endosomal traffic and various signaling pathways makes it an attractive target for the development of new therapeutic agents for various diseases, including cancer, neurodegenerative diseases, and diseases associated with endosomal dysfunction.

In conclusion, ENTR1 is a key regulator of endosomal traffic and has been shown to play a role in the regulation of various cellular processes. Its involvement in the regulation of endosomal traffic makes it an attractive target for the development of new therapeutic agents for various diseases . Further research is needed to fully understand the role of ENTR1 in the regulation of endosomal traffic and to develop new therapeutic approaches for the treatment of various diseases.

Protein Name: Endosome Associated Trafficking Regulator 1

Functions: Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). Plays a role in the formation of cilia (PubMed:27767179). Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity)

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