EMP2: Key Regulator of Immune Response and Diseases (G2013)

Target Name: EMP2

NCBI ID: G2013

EMP2: Key Regulator of Immune Response and Diseases

EMP2 (EMP2_HUMAN) is a protein that is expressed in various tissues of the human body. It is a key regulator of the immune response and has been implicated in a number of diseases, including cancer.

EMP2 is a member of the EMP family of proteins, which are involved in the regulation of inflammation and immune responses. The EMP family of proteins are characterized by the presence of a unique domain called the Ensign-D gene (END), which is responsible for the production of electrophysiological signals that are involved in the regulation of gene expression.

EMP2 is a 21-kDa protein that is expressed in a variety of tissues, including muscle, pancreas, and brain. It is primarily localized to the cytoplasm of cells and is involved in the regulation of a wide range of cellular processes, including cell signaling, cell adhesion, and the regulation of inflammation.

One of the most significant functions of EMP2 is its role in the regulation of the immune response. EMP2 has been shown to play a key role in the development of cancer, and is often expressed in tumors. It is also involved in the regulation of inflammation, and has been shown to play a role in the development of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.

In addition to its role in the immune response, EMP2 is also involved in the regulation of a variety of other cellular processes, including cell signaling, cell adhesion, and the regulation of cell cycle progression. It is a component of several signaling pathways that are involved in the regulation of cellular processes, including the T-cell signaling pathway and the regulation of the cell cycle.

EMP2 has also been shown to play a role in the regulation of cellular processes that are important for the development and progression of neurodegenerative diseases. It is a component of several neurotransmitter signaling pathways that are involved in the regulation of the nervous system, and has been shown to play a role in the development of conditions such as Alzheimer's disease and Parkinson's disease.

In conclusion, EMP2 (EMP2_HUMAN) is a protein that is expressed in various tissues of the human body and is involved in a wide range of cellular processes. It is a key regulator of the immune response and has been implicated in a number of diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. Further research is needed to fully understand the role of EMP2 in these processes and to develop effective treatments.

Protein Name: Epithelial Membrane Protein 2

Functions: Functions as a key regulator of cell membrane composition by regulating protein surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Regulates transepithelial migration of neutrophils into the alveolar lumen, potentially via mediation of cell surface expression of adhesion markers and lipid raft formation (By similarity). Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration and cell contraction through PTK2 and SRC activation (PubMed:21637765, PubMed:22728127). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (PubMed:19494199). Positively regulates cell proliferation (PubMed:24814193). Plays a role during cell death and cell blebbing (PubMed:12107182). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (PubMed:23334331). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PubMed:16487956). Plays a role in placental angiogenesis and uterine natural killer cell regulation at the maternal-fetal placental interface, however not required in the maternal tissues for a viable pregnancy (By similarity). Involved in the early stages of embryogenic development and cardiogenesis, potentially via regulation of epithelial-mesenchymal transition timing (By similarity). May play a role in glomerular filtration (By similarity)

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