ENDOV: A Potential Drug Target for Inosine-Containing RNAs (G284131)

Target Name: ENDOV

NCBI ID: G284131

ENDOV: A Potential Drug Target for Inosine-Containing RNAs

ENDOV (Inosine-specific endoribonuclease) is a protein that is expressed in various cell types, including the brain, heart, liver, and kidneys. It is a key enzyme in the endoribonuclease pathway, which is a process that helps to break down complex RNA structures. This pathway is involved in the regulation of various cellular processes, including DNA replication, gene expression, and cell signaling.

One of the unique features of ENDOV is its specificity for inosine, a nucleoside that is commonly found in RNA viruses such as herpes simplex virus (HSV) and varicella-zoster virus (VZV). Inosine is a potent inhibitor of the activity of the endoribonuclease enzyme, which means that ENDOV is able to cleave the ends of RNA molecules that contain inosine.

ENDOV's involvement in the endoribonuclease pathway has important implications for the study of RNA viruses. In particular, it has been shown that ENDOV is involved in the regulation of HSV and VZV replication. These viruses can cause painful sores on the skin and can also cause more serious complications, such as cancer and liver disease, if left untreated.ENDOV's ability to specifically interact with inosine has been shown to make it an attractive target for drug development.

In addition to its role in virus replication, ENDOV is also involved in the regulation of cellular processes that are important for cell survival. For example, ENDOV has been shown to play a role in the regulation of cell adhesion, a process that is critical for the formation of tissues and organs.ENDOV's ability to interact with inosine has also been shown to be involved in the regulation of cell signaling pathways, including the regulation of cell proliferation and apoptosis.

ENDOV's potential as a drug target is further demonstrated by its ability to interact with a variety of small molecules, including inhibitors and activators. This suggests that ENDOV may be able to be effectively targeted by small molecules that are currently being used to treat a variety of diseases. Additionally, ENDOV's expression in a variety of tissues makes it an attractive target for drug development due to its broad therapeutic potential.

In conclusion, ENDOV (Inosine-specific endoribonuclease) is a protein that is expressed in various cell types and is involved in the regulation of various cellular processes, including cell adhesion and signaling pathways. Its specificity for inosine makes it an attractive target for drug development, particularly for the treatment of viruses such as HSV and VZV that cause painful sores and more serious complications. Additionally, ENDOV's role in the regulation of cellular processes important for cell survival makes it a potential target for the treatment of a variety of diseases.

Protein Name: Endonuclease V

Functions: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:23912683, PubMed:23912718, PubMed:27573237, PubMed:31703097, PubMed:25195743). Active against both single-stranded and double-stranded RNAs (PubMed:31703097, PubMed:25195743). Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs) (PubMed:23912718). Cleaves mRNAs and tRNAs containing inosine (PubMed:23912683, PubMed:31703097). Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3' (PubMed:23912718, PubMed:27573237). Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing (Probable). Binds branched DNA structures (PubMed:23139746)

More Common Targets