Target Name: ELK1
NCBI ID: G2002
Other Name(s): ETS transcription factor ELK1, transcript variant 1, also known as 5'UTR long or 5'UTRL | ELK1 variant 2 | ETS domain-containing protein Elk-1 (isoform a) | ELK1_HUMAN | ETS-like gene 1 | tyrosine kin

ELK1: A Potential Drug Target and Biomarker

ELK1, also known as ETL1 or 5'UTR long, is a transcription factor that plays a crucial role in regulating gene expression in various organisms, including humans. It is a member of the ELK family of transcription factors, which are known for their ability to enhance the stability of RNA polymerase II and facilitate the initiation of transcription. ELS1, the Escherichia coli transcription factor, is the best-known member of this family.

ELK1 is expressed in a wide range of tissues and cells in the human body, including muscle, heart, brain, and various cell types. It is highly expressed in the brain, where it is found at relatively high levels in the prefrontal cortical cortex, frontal eye fields, and cerebellum. ELK1 is also expressed in other organs, including the lungs, liver, pancreas, and kidneys.

The function of ELK1 is highly conserved across different species. It is involved in the regulation of gene expression by binding to specific DNA sequences and by regulating the activity of RNA polymerase II. ELK1 can activate or repress gene expression depending on the specific context. For example, in response to a DNA template that contains a specific binding site, ELK1 can activate gene expression, while in response to a DNA template that does not contain a binding site, ELK1 can repress gene expression.

ELK1 has also been shown to play a role in various cellular processes, including cell growth, apoptosis, and inflammation. For example, ELK1 has been shown to be involved in the regulation of cell cycle progression, and it has been implicated in the development and progression of certain diseases, such as cancer. ELK1 has also been shown to be involved in the regulation of inflammation, and it has been implicated in the development of certain autoimmune diseases.

As a potential drug target, ELK1 has been identified as a target for small molecules, including inhibitors of the ELK1 enzyme. These inhibitors have been shown to have a range of biological effects, including the inhibition of cancer cell growth, the inhibition of cell division, and the inhibition of inflammation.

In addition to its potential as a drug target, ELK1 has also been identified as a potential biomarker for various diseases. For example, ELK1 has been shown to be highly expressed in certain types of cancer, and it has been used as a biomarker for the diagnosis and prognosis of these diseases. ELK1 has also been shown to be involved in the regulation of cellular processes that are implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Overall, ELK1 is a highly conserved transcription factor that plays a crucial role in regulating gene expression in various organisms. Its function as a drug target and biomarker makes it an attractive target for the development of new therapies for a variety of diseases. Further research is needed to fully understand the role of ELK1 in various biological processes and to develop effective inhibitors of the ELK1 enzyme.

Protein Name: ETS Transcription Factor ELK1

Functions: Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity)

More Common Targets

ELK2AP | ELK3 | ELK4 | ELL | ELL2 | ELL2P1 | ELL3 | ELMO1 | ELMO2 | ELMO3 | ELMOD1 | ELMOD2 | ELMOD3 | ELN | ELOA | ELOA-AS1 | ELOA2 | ELOA3BP | ELOA3DP | ELOA3P | ELOB | ELOC | ELOF1 | Elongation Factor 1 Complex | Elongation of very long chain fatty acids protein | Elongin (SIII) complex | ELOVL1 | ELOVL2 | ELOVL2-AS1 | ELOVL3 | ELOVL4 | ELOVL5 | ELOVL6 | ELOVL7 | ELP1 | ELP2 | ELP3 | ELP4 | ELP5 | ELP6 | ELSPBP1 | EMB | EMBP1 | EMC1 | EMC1-AS1 | EMC10 | EMC2 | EMC3 | EMC3-AS1 | EMC4 | EMC6 | EMC7 | EMC8 | EMC9 | EMCN | EMD | EME1 | EME2 | EMG1 | EMID1 | EMILIN1 | EMILIN2 | EML1 | EML2 | EML2-AS1 | EML3 | EML4 | EML4-AS1 | EML5 | EML6 | EMP1 | EMP2 | EMP2P1 | EMP3 | EMSLR | EMSY | EMX1 | EMX2 | EMX2OS | EN1 | EN2 | ENAH | ENAM | ENC1 | ENDOD1 | ENDOG | Endogenous Retrovirus group K Env polyprotein (ERVK) | Endogenous retrovirus group K member 25 Pol protein-like, transcript variant X1 | EndoGlyx-1 | Endoplasmic reticulum collagen prolyl 3-hydroxylation complex | Endothelin receptor | Endothelin-Converting Enzymes (ECE) | Endothiapepsin | ENDOU | ENDOV | ENG | ENGASE | ENHO | ENKD1 | ENKUR