ELK4: A Potential Drug Target and Biomarker (G2005)

Target Name: ELK4

NCBI ID: G2005

ELK4: A Potential Drug Target and Biomarker

The elk-4 gene, located on chromosome 18q21, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. The elk-4 gene encodes a protein known as ELK4, which is a member of the evolutionarily conserved Elk family of proteins. ELK4 has been shown to play a crucial role in various cellular processes, including cell adhesion, migration, and survival.

The elk-4 gene has also been linked to several diseases and conditions, including cancer, neurodegenerative disorders, and autoimmune diseases. For example, studies have shown that high levels of ELK4 are associated with an increased risk of lung cancer and neurofibrillary tangles in Alzheimer's disease. Additionally, individuals with certain genetic mutations, such as those with the BRCA gene mutation, have been shown to have increased levels of ELK4 and are at an increased risk of developing breast cancer.

In addition to its potential links to disease, ELK4 has also been shown to be a promising biomarker for several diseases. For example, ELK4 has been used as a marker for cancer, as individuals with high levels of ELK4 are more likely to develop cancer. Additionally, ELK4 has been used as a biomarker for neurodegenerative disorders, as individuals with neurodegenerative disorders tend to have lower levels of ELK4.

Despite its potential as a drug target and biomarker, much more research is needed to fully understand the role of ELK4 in various diseases. Currently, there are no approved drugs that target ELK4 directly. However, researchers are actively exploring the potential benefits and risks of targeting ELK4, as well as other genes associated with various diseases, in order to develop new treatments for these conditions.

In conclusion, ELK4 is a promising drug target and biomarker for a variety of diseases. Further research is needed to fully understand its role and potential as a treatment option.

Protein Name: ETS Transcription Factor ELK4

Functions: Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously

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