LL: A Protein Role in RNA Polymerase II and Gene Expression Regulation

Target Name: ELL

NCBI ID: G8178

LL: A Protein Role in RNA Polymerase II and Gene Expression Regulation

ELL (Elongation factor for RNA polymerase II) is a protein that plays a crucial role in the process of transcription in the RNA polymerase II complex. It is a key factor in the elongation of RNA polymerase II, which is the enzyme responsible for transcribing DNA into RNA.

LL is a 25 kDa protein that is composed of two subunits: alpha and beta. The alpha subunit consists of 120 amino acids, while the beta subunit consists of 80 amino acids. Both subunits contain a unique domain that is specific to ELL.

The alpha subunit of ELL contains a single domain that is composed of a series of amino acids that are involved in a unique process called \"ellen\". This domain is responsible for the elongation of RNA polymerase II by providing a platform for the addition of the DNA template to the growing RNA molecule.

The beta subunit of ELL contains a unique domain called \"B32\". This domain is involved in the regulation of the activity of RNA polymerase II and is thought to play a role in the inhibition of its activity in cases of RNA hyperaccumulation.

In addition to its role in the elongation of RNA polymerase II, ELL is also involved in the regulation of gene expression. This is done through the interaction of ELL with specific DNA sequences, which allows it to modulate the activity of RNA polymerase II and other transcription factors.

ELL has been shown to play a role in the regulation of gene expression in various organisms, including humans. For example, studies have shown that ELL can inhibit the activity of RNA polymerase II and reduce the levels of RNA output in cells. This can lead to the translation of specific genes being reduced or even silent.

This lack of RNA output is important for the regulation of gene expression and can lead to the suppression of potentially harmful or undesirable genes. In addition, the elongation of RNA polymerase II by ELL is also critical for the regulation of gene expression, as the rate at which RNA is produced determines the amount of RNA available for translation into protein.

Based on these findings, ELL is a promising drug target and has the potential to be used for a variety of therapeutic applications. For example, if ELL is inhibited, the levels of RNA output from the gene of interest will be reduced, which can result in the translation of specific genes being reduced or even silenced. This can lead to the inhibition of potentially harmful or undesirable genes and improve overall health.

In addition to its potential therapeutic applications, ELL is also a valuable biomarker for the diagnosis and monitoring of various diseases. For example, the levels of ELL in RNA can be used as a marker for the diagnosis of RNA polymerase II-related diseases, such as cancer.

Overall, ELL is a protein that plays a critical role in the regulation of gene expression and has the potential to be used for a variety of therapeutic and diagnostic applications. Further research is needed to fully understand its mechanisms of action and its potential therapeutic applications.

Protein Name: Elongation Factor For RNA Polymerase II

Functions: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation

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