ELOB: A Protein Involved in RNA Splicing and Gene Expression (G6923)

Target Name: ELOB

NCBI ID: G6923

ELOB: A Protein Involved in RNA Splicing and Gene Expression

ELOB (Transcription Elongation Factor B Polypeptide 2) is a protein that plays a critical role in the regulation of gene expression in eukaryotic cells. It is a member of the ELF (Transcription Elongation Factor) family, which includes a variety of proteins that share similar structures and functions. ELOB is widely expressed in many different tissues and cells, and it has been implicated in a number of cellular processes, including cell growth, differentiation, and stress response.

One of the key functions of ELOB is its role in the regulation of RNA splicing, which is the process by which the genetic material of a cell is transcribed into RNA. RNA splicing is a highly regulated process that involves the removal of non-coding regions from the RNA molecule and the addition of coding regions. This process is essential for the production of a wide variety of RNA molecules that are involved in cellular signaling and function. ELOB is involved in the regulation of RNA splicing by a process called exon shuffling.

Exon shuffling is a process in which the order in which the exons that make up a particular RNA molecule are rearranged. This can be a critical step in the regulation of RNA splicing, as it allows the cell to produce a variety of different RNA molecules with different combinations of gene information. ELOB is involved in exon shuffling by binding to specific regions of the DNA that contain the instructions for RNA splicing. It does this by using a unique set of binding sites on the DNA to recognize and interact with the regions of the RNA molecule that are being transcribed.

ELOB has also been shown to be involved in the regulation of gene expression in a variety of different contexts. For example, studies have shown that ELOB can inhibit the activity of the RNA polymerase II, a protein that is responsible for transcribing DNA into RNA. This inhibition can lead to the translation of specific genes into RNA, which can then be processed into proteins and involved in cellular signaling and function. Additionally, ELOB has been shown to play a role in the regulation of cell cycle progression, as well as in the stress response.

Given its involvement in a wide range of cellular processes, ELOB is an attractive target for research and development. There is ongoing research into the use of small molecules and other compounds to inhibit or activate the activity of ELOB, with the goal of developing new treatments for a variety of diseases. For example, some researchers are studying the potential of small molecules that can inhibit ELOB activity to treat cancer, while others are looking at the potential of ELOB-based therapies for treating genetic disorders.

Overall, ELOB is a complex and important protein that is involved in a wide range of cellular processes. Its role in the regulation of RNA splicing and gene expression makes it an attractive target for research and development, with the potential to revolutionize our understanding of the biology of cells and the potential to lead to new treatments for a variety of diseases.

Protein Name: Elongin B

Functions: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity)

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