Target Name: NUFIP1
NCBI ID: G26747
Other Name(s): Rsa1 | NUFIP | Nuclear FMR1 interacting protein 1 | bA540M5.1 | nuclear FMR1 interacting protein 1 | Nuclear FMR1-interacting protein 1 | Nuclear fragile X mental retardation protein-interacting protein 1 | FMR1-interacting protein NUFIP1 | nuclear FMRP-interacting protein 1 | nuclear fragile X mental retardation protein interacting protein 1 | OTTHUMP00000018342 | Nuclear FMRP-interacting protein 1 | BA540M5.1 | NUFP1_HUMAN | NUFIP1, FMR1 interacting protein 1 | Nuclear fragile X mental retardation-interacting protein 1

NUFIP1: A Potential Drug Target for DNA Double-Strand Break Repair and Cell Growth

NUFIP1 (Nrf2-Ubiquitin-Aspartate-1) is a protein that is expressed in various tissues throughout the body. It is a key regulator of DNA double-strand break repair and is a potential drug target in the treatment of various diseases.

NUFIP1 is a 21-kDa protein that is composed of a N-terminal domain, a U-terminal domain, and an C-terminal domain. The N-terminal domain is composed of a single amino acid, Asp-21, which is a conserved residue that is involved in protein-protein interactions. The U-terminal domain is composed of a single amino acid, Asp-20, which is also a conserved residue that is involved in protein-protein interactions. The C-terminal domain is composed of a series of amino acids, including Asp-19, Asp-18, Asp-17, and Asp-16, which are also conserved residues that are involved in protein-protein interactions.

NUFIP1 is a non-histone protein that is not associated with histone modifications. Instead, it is a member of the Nrf2 gene family, which is known for its role in the regulation of DNA double-strand break repair. Nrf2 is a transcription factor that is involved in the regulation of various cellular processes, including DNA replication, gene expression, and stress response.

NUFIP1 is involved in the repair of double-strand breaks in DNA. When a double-strand break occurs in DNA, NUFIP1 helps to repair it by interacting with the damaged strand and facilitating the formation of a new double-strand. This process is critical for the regulation of DNA replication and the prevention of genetic mutations.

NUFIP1 is also involved in the regulation of cell growth and division. It helps to ensure that cells divide and grow in a controlled manner, and it also helps to prevent the formation of cancerous cells. This is done by regulating the activity of various cellular signaling pathways, including the TGF-β pathway, which is involved in cell growth, differentiation, and survival.

In addition to its role in the regulation of DNA double-strand break repair and cell growth, NUFIP1 is also involved in the regulation of inflammation. It helps to control the activity of immune cells and supports the regulation of inflammation. This is done by regulating the activity of various signaling pathways, including the NF-kappa-B pathway, which is involved in inflammation and immune response.

NUFIP1 is a potential drug target because of its role in the regulation of DNA double-strand break repair, cell growth and division, and inflammation. Its activity as a drug target makes it an attractive target for the development of new treatments for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

In conclusion, NUFIP1 is a non-histone protein that is involved in the regulation of DNA double-strand break repair, cell growth and division, and inflammation. Its activity as a drug target makes it an attractive target for the development of new treatments for various diseases. Further research is needed to fully understand the role of NUFIP1 in the regulation of DNA double-strand break repair and the development of new treatments.

Protein Name: Nuclear FMR1 Interacting Protein 1

Functions: Binds RNA

More Common Targets

NUFIP2 | NUGGC | NUMA1 | NUMB | NUMBL | NUP107 | Nup107-160 complex | NUP133 | NUP153 | NUP155 | NUP160 | NUP188 | NUP205 | NUP210 | NUP210L | NUP210P1 | NUP210P2 | NUP214 | NUP35 | NUP37 | NUP42 | NUP43 | NUP50 | NUP50-DT | NUP54 | NUP58 | NUP62 | NUP62CL | NUP85 | NUP88 | NUP93 | NUP98 | NUPR1 | NUPR2 | NUS1 | NUS1P1 | NUS1P3 | NUSAP1 | NUTF2 | NUTF2P4 | NUTM1 | NUTM2A | NUTM2A-AS1 | NUTM2B | NUTM2B-AS1 | NUTM2D | NUTM2E | NUTM2F | NUTM2G | NVL | NWD1 | NWD2 | NXF1 | NXF2 | NXF3 | NXF4 | NXF5 | NXN | NXNL1 | NXNL2 | NXPE1 | NXPE2 | NXPE3 | NXPE4 | NXPH1 | NXPH2 | NXPH3 | NXPH4 | NXT1 | NXT2 | NXTAR | NYAP1 | NYAP2 | NYNRIN | NYX | OACYLP | OAF | OARD1 | OAS1 | OAS2 | OAS3 | OASL | OAT | OATP1 | OAZ1 | OAZ2 | OAZ3 | OBI1 | OBI1-AS1 | OBP2A | OBP2B | OBSCN | OBSCN-AS1 | OBSL1 | OC90 | OCA2 | OCEL1 | OCIAD1 | OCIAD2 | OCLM