Target Name: GGCX
NCBI ID: G2677
Other Name(s): GGCX variant 1 | peptidyl-glutamate 4-carboxylase | GC | VKCFD1 | Vitamin K-dependent gamma-carboxylase | Gamma-glutamyl carboxylase | GGCX variant 2 | Vitamin K-dependent gamma-carboxylase (isoform 2) | Gamma-glutamyl carboxylase, transcript variant 1 | gamma-glutamyl carboxylase | Gamma-glutamyl carboxylase, transcript variant 2 | Peptidyl-glutamate 4-carboxylase | Vitamin K-dependent carboxylase | Vitamin K-dependent gamma-carboxylase (isoform 1) | VKGC_HUMAN | Vitamin K gamma glutamyl carboxylase

GGCX: A Potential Drug Target and Biomarker for Neurodegenerative Diseases

GGCX, also known as GGCX variant 1, is a protein that is expressed in various tissues throughout the body, including the brain, lungs, heart, kidneys, and intestines. It is a member of the G protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a critical role in cellular signaling.

GGCX is a 21-kDa protein that is expressed in the brain, where it is involved in the regulation of neural circuits and is thought to play a role in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. It is also expressed in other tissues and is involved in various physiological processes, including cell signaling, angiogenesis, and inflammation.

Recent studies have identified GGCX as a potential drug target for a variety of diseases, including neurodegenerative diseases, cancer, and autoimmune disorders. GGCX has also been shown to be involved in various signaling pathways, including the TGF-β pathway, which is involved in cell signaling and is often disrupted in neurodegenerative diseases.

One of the potential benefits of targeting GGCX is its potential to modulate the activity of other genes that are involved in the development and progression of neurodegenerative diseases. For example, GGCX has been shown to interact with the neurotransmitter GABA, which is involved in the regulation of anxiety and depression. By modulating the activity of GABA, GGCX may be able to reduce the symptoms of these diseases.

Another potential mechanism by which GGCX may be targeted is its role in the regulation of angiogenesis, which is the process by which new blood vessels are formed. GGCX has been shown to be involved in the regulation of angiogenesis and has been shown to play a role in the development of blood-brain barrier (BBB) breakdown, which is a hallmark of neurodegenerative diseases. By targeting GGCX, researchers may be able to develop new treatments for neurodegenerative diseases that specifically target this protein.

In addition to its potential role in modulating the activity of other genes, GGCX is also thought to be a potential biomarker for a variety of neurodegenerative diseases. The GGCX protein is expressed in various tissues throughout the body and has been shown to be involved in the regulation of various physiological processes, including cell signaling and angiogenesis. By analyzing the expression of GGCX in different tissues and using techniques such as Western blotting, researchers may be able to develop new diagnostic tests for neurodegenerative diseases based on the level of GGCX expression in these tissues.

GGCX is also thought to be involved in the regulation of inflammation, which is a critical aspect of many neurodegenerative diseases. For example, GGCX has been shown to be involved in the regulation of the immune response and has been shown to play a role in the development of neuroinflammation. By targeting GGCX, researchers may be able to develop new treatments for neurodegenerative diseases that specifically target this protein and its role in inflammation.

In conclusion, GGCX is a protein that is expressed in various tissues throughout the body and is involved in various physiological processes, including cell signaling, angiogenesis, and inflammation. As a result, GGCX is a potential drug target and biomarker for a variety of neurodegenerative diseases. Further research is needed to fully understand the role of GGCX in these diseases and to develop effective treatments based on this protein.

Protein Name: Gamma-glutamyl Carboxylase

Functions: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide

More Common Targets

GGH | GGN | GGNBP1 | GGNBP2 | GGPS1 | GGT1 | GGT2P | GGT3P | GGT5 | GGT6 | GGT7 | GGT8P | GGTA1 | GGTLC1 | GGTLC2 | GGTLC3 | GH1 | GH2 | GHDC | GHITM | GHR | GHRH | GHRHR | GHRL | GHRLOS | GHSR | GID4 | GID8 | GIGYF1 | GIGYF2 | GIHCG | GIMAP1 | GIMAP1-GIMAP5 | GIMAP2 | GIMAP3P | GIMAP4 | GIMAP5 | GIMAP6 | GIMAP7 | GIMAP8 | GIMD1 | GIN1 | GINM1 | GINS complex | GINS1 | GINS2 | GINS3 | GINS4 | GIP | GIPC1 | GIPC2 | GIPC3 | GIPR | GIT1 | GIT2 | GJA1 | GJA10 | GJA1P1 | GJA3 | GJA4 | GJA5 | GJA8 | GJA9 | GJA9-MYCBP | GJB1 | GJB2 | GJB3 | GJB4 | GJB5 | GJB6 | GJB7 | GJC1 | GJC2 | GJC3 | GJD2 | GJD3 | GJD4 | GK | GK2 | GK3 | GK5 | GKAP1 | GKN1 | GKN2 | GKN3P | GLA | GLB1 | GLB1L | GLB1L2 | GLB1L3 | GLC1C | GLCCI1 | GLCCI1-DT | GLCE | GLDC | GLDN | GLE1 | GLG1 | GLI1 | GLI2