Target Name: LIPM
NCBI ID: G340654
Other Name(s): Lipase member M | LIPL3 | bA304I5.1 | LIPM_HUMAN | lipase-like, ab-hydrolase domain containing 3 | Lipase-like, ab-hydrolase domain containing 3 | lipase family member M | Lipase M | Lipase family member M | lipase M | lipase-like abhydrolase domain-containing protein 3 | Lipase-like abhydrolase domain-containing protein 3

Understanding The Role of LIPM in Diseases

Lipase member M (LIPM) is a protein that is expressed in various cell types of the human body, including liver, muscle, and heart. It is a member of the Lipase family, which includes enzymes that are involved in lipid metabolism. LIPM is a 22kDa protein that is expressed in high levels in the liver and muscle tissues. It plays a crucial role in the metabolism of lipids, which are essential for various cellular functions.

The Importance of Lipid Metabolism

Lipids are essential for various cellular functions, including energy production, insulation, and cell membrane structure. They are also involved in the absorption of certain vitamins and minerals. Therefore, the metabolism of lipids is critical for maintaining cellular health and function.

Lipase member M is involved in the metabolism of fatty acids, which are essential for various cellular functions. It is a key enzyme in the triacylglycerol (TAG) metabolism pathway, which is the primary pathway for the metabolism of triacylglycerols in the liver. LIPM is involved in the conversion of TAGs to TAG-free intermediates. This conversion is critical for the production of energy in the form of ATP.

Diseases and Abnormalities

Lipase member M is involved in various cellular processes that are important for maintaining cellular health and function. Therefore, genetic or cellular changes that occur in LIPM can lead to various diseases and abnormalities. For example, mutations in the LIPM gene have been associated with various diseases, including cardiovascular disease, diabetes, and obesity.

In addition, LIPM is also involved in the regulation of cellular processes that are important for the development and progression of cancer. Therefore, changes in LIPM expression have been observed in various cancer types, including breast, ovarian, and colorectal cancer.

Drugs that Target LIPM

LIPM is a drug target that has been identified as a potential therapeutic target for various diseases. Several drugs that target LIPM have been developed and are in various stages of clinical development. These drugs include:

1. LIPM inhibitors: These drugs work by inhibiting the activity of LIPM, which can reduce the production of TAGs and improve the levels of energy in the liver.

2. LIPM activators: These drugs work by increasing the activity of LIPM, which can increase the production of TAGs and improve the levels of energy in the liver.

3. LIPM modulators: These drugs work by altering the activity of LIPM, which can reduce the production of TAGs and improve the levels of energy in the liver.

Current Research

LIPM is a protein that is involved in various cellular processes that are important for maintaining cellular health and function. Therefore, researchers are interested in understanding its role in the development and progression of various diseases. Current research is focused on the identification of LIPM as a potential therapeutic target for various diseases, including cancer and cardiovascular disease.

Conclusion

Lipase member M (LIPM) is a protein that is involved in various cellular processes that are important for maintaining cellular health and function. Its role in the metabolism of lipids is critical for the production of energy in the form of ATP. Therefore, LIPM is a potential therapeutic target for various diseases, including cancer and cardiovascular disease. Several drugs that target LIPM have been developed and are in various stages of clinical development. Further research is needed to fully understand the role of LIPM in the development and progression of various diseases.

Protein Name: Lipase Family Member M

Functions: Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers

More Common Targets

LIPN | Lipoxygenase | Liprin-beta-1-like | LIPT1 | LIPT2 | LIPT2-AS1 | LITAF | Liver Bile Transporters (LBAT) | LIX1 | LIX1-AS1 | LIX1L | LKAAEAR1 | LKB1-LIP1-SMAD4 complex | LL22NC03-63E9.3 | LLCFC1 | LLGL1 | LLGL2 | LLPH | LMAN1 | LMAN1L | LMAN2 | LMAN2L | LMBR1 | LMBR1L | LMBRD1 | LMBRD2 | LMCD1 | LMCD1-AS1 | LMF1 | LMF2 | LMLN | LMNA | LMNB1 | LMNB2 | LMNTD1 | LMNTD2 | LMNTD2-AS1 | LMO1 | LMO2 | LMO3 | LMO4 | LMO7 | LMO7-AS1 | LMO7DN | LMOD1 | LMOD2 | LMOD3 | LMTK2 | LMTK3 | LMX1A | LMX1B | LMX1B-DT | LNC-LBCS | LNCAROD | LNCARSR | LNCATV | LNCNEF | LNCOC1 | LNCOG | LNCPRESS1 | LNCRI | LNCRNA-ATB | LNCRNA-IUR | LNCTAM34A | LNP1 | LNPEP | LNPK | LNX1 | LNX1-AS1 | LNX2 | LOC100127946 | LOC100127955 | LOC100128002 | LOC100128028 | LOC100128050 | LOC100128059 | LOC100128079 | LOC100128093 | LOC100128164 | LOC100128242 | LOC100128288 | LOC100128317 | LOC100128361 | LOC100128398 | LOC100128494 | LOC100128593 | LOC100128770 | LOC100128966 | LOC100128988 | LOC100129034 | LOC100129098 | LOC100129148 | LOC100129175 | LOC100129203 | LOC100129215 | LOC100129316 | LOC100129381 | LOC100129434 | LOC100129455 | LOC100129534