Potential Therapeutic Targets and Biomarkers for Matrix Metalloproteinase (MMP) 13

Target Name: MMP13

NCBI ID: G4322

Potential Therapeutic Targets and Biomarkers for Matrix Metalloproteinase (MMP) 13

Matrix metalloproteinase (MMP) 13 (also known as collagenase 3) is a protein that is involved in the breakdown of collagen, a protein that is found in the skin, bones, and connective tissue. MMP 13 is a member of the MMP family of proteins, which are known for their ability to regulate the extracellular matrix (ECM) and play a role in tissue repair and regeneration.

MMP 13 is a potent enzyme that has been shown to break down collagen in a variety of tissues, including the skin, bones, and tendons. This breakdown of collagen can lead to the formation of matrix metalloproteinases (MMPs), which are known for their MMP 13 is also involved in the regulation of the cytoskeleton and has been shown to play a role in the development and maintenance of cancer.

Despite its potential role in tissue remodeling and cancer development, MMP 13 has until now been considered a relatively unimportant protein. However, recent studies have shown that MMP 13 may also have potential as a drug target or biomarker.

One potential mechanism by which MMP 13 could be targeted as a drug is through its role in the regulation of the cytoskeleton. MMP 13 is known to play a role in the organization and stability of the cytoskeleton and has been shown to affect the distribution of vasodilation in response to different stimuli. This suggests that MMP 13 may be a useful target for drugs that are designed to modulate cytoskeleton function.

Another potential mechanism by which MMP 13 could be used as a drug target is its role in the regulation of cell signaling pathways. MMP 13 has been shown to play a role in the regulation of several signaling pathways, including the TGF-β pathway and the Wnt pathway. These pathways are involved in the regulation of cell growth, differentiation, and survival, and are thought to be important targets for drugs that are designed to modulate these processes.

In addition to its potential role as a drug target, MMP 13 has also been shown to be a potential biomarker for several types of cancer. For example, MMP 13 has been shown to be overexpressed in a variety of cancer tissues and has been used as a biomarker for several types of cancer, including breast, ovarian, and colorectal cancers.

Given its potential as a drug target and biomarker, MMP 13 is an attractive target for further research and development. Future research will focus on the potential role of MMP 13 in drug discovery and tumor treatment.

Protein Name: Matrix Metallopeptidase 13

Functions: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion

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