MMP24: A Potential Drug Target for Tissue Health and Disease (G10893)

Target Name: MMP24

NCBI ID: G10893

MMP24: A Potential Drug Target for Tissue Health and Disease

MMP24 is a protein that is expressed in various tissues throughout the body, including the liver, pancreas, and gastrointestinal tract. It is a member of the matrix metalproteinase (MMP) family, which are a group of enzymes that can cleave extracellular matrix (ECM) components and play a role in tissue remodeling and regeneration.

MMP24 is involved in the regulation of cellular processes that are important for tissue repair and regeneration, including the removal of damaged or unnecessary ECM components. It is also involved in the production of new ECM components, such as collagen and extracellular matrix proteins, which are important for tissue structure and function.

MMP24 has been identified as a potential drug target due to its involvement in a variety of cellular processes that are important for tissue health and disease. It is involved in the regulation of cell signaling pathways that are important for tissue development, wound healing, and inflammation. It is also involved in the regulation of cellular processes that are important for the production and degradation of ECM components, which can be targeted as potential therapeutic targets.

One of the potential benefits of targeting MMP24 is its potential to modulate the production of ECM components that are involved in tissue inflammation and fibrosis. ECM components that are produced in response to tissue injury or inflammation, such as ECM components that contribute to the formation of immune complexes and tissue repair mechanisms, can be targeted as potential therapeutic targets. By modulating the production of these ECM components, MMP24 may be able to reduce the production of pro-inflammatory cytokines and other tissue damage molecules, which can be beneficial for reducing inflammation and promoting tissue repair.

Another potential benefit of targeting MMP24 is its potential to modulate the production of ECM components that are involved in tissue remodeling and regeneration. ECM components that are produced in response to tissue growth, such as ECM components that contribute to the formation of new tissue structures, can be targeted as potential therapeutic targets. By modulating the production of these ECM components, MMP24 may be able to promote tissue growth and repair, which can be beneficial for treating a variety of diseases and conditions, such as cancer, neurodegenerative diseases, and wound injuries.

MMP24 is also involved in the regulation of cellular processes that are important for the production and degradation of ECM components. ECM components that are produced in response to tissue injury or inflammation, such as ECM components that contribute to the formation of immune complexes and tissue repair mechanisms, can be targeted as potential therapeutic targets. By modulating the production and degradation of these ECM components, MMP24 may be able to reduce the production of pro-inflammatory cytokines and other tissue damage molecules, which can be beneficial for reducing inflammation and promoting tissue repair.

Targeting MMP24 may also have potential benefits for the treatment of certain cancers. MMP24 has been shown to be involved in the regulation of cellular processes that are important for cancer cell growth and survival. By targeting MMP24, researchers may be able to inhibit the production of ECM components that contribute to cancer cell growth and survival, which can be beneficial for treating a variety of cancers.

In conclusion, MMP24 is a protein that is involved in a variety of cellular processes that are important for tissue health and disease. It is a potential drug target due to its involvement in the regulation of cellular processes that are important for tissue development, wound healing, and inflammation. By targeting MMP24, researchers may be able to modulate the production of ECM components that are involved in these processes, which can be beneficial for treating a variety of diseases and conditions. Further research is needed to fully understand the potential benefits and risks of targeting MMP24.

Protein Name: Matrix Metallopeptidase 24

Functions: Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity)

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