Target Name: RNASE13
NCBI ID: G440163
Other Name(s): ribonuclease A family member 13 (inactive) | HEL-S-86p | Probable inactive ribonuclease-like protein 13 | RNS13_HUMAN | ribonuclease A L1 | Ribonuclease A family member 13 (inactive) | RAL1 | Ribonuclease-like protein 13 | ribonuclease 13 | Ribonuclease 13 | epididymis secretory sperm binding protein Li 86p | ribonuclease, RNase A family, 13 (non-active) | ribonuclease-like protein 13

Unlocking the Potential of RNASE13: A Novel Drug Target and Biomarker

Introduction

Ribonuclease A family member 13 (RNASE13) is a highly conserved non-coding RNA molecule that plays a critical role in various cellular processes. Its function in cell biology is still poorly understood, but research has shown that it is involved in a wide range of cellular processes, including DNA repair, gene expression, and cell signaling. Its unique structure and subcellular localization have made it an attractive target for drug development. In this article, we will explore the potential of RNASE13 as a drug target and biomarker.

The RNase13 Family

The RNase13 gene is located on chromosome 16 and encodes a protein with 13 subunits.1 The subunits are involved in the different stages of RNA degradation, including RNA-mediated DNA damage repair,2 gene expression,3 and cell signaling.4

Function and Localization

RNase13 is involved in various cellular processes that are crucial for cell survival. Its primary function is the processing of RNA for degradation by the 26S ribosome.5 This processing generates 20-nm particles, which are then removed by the 21S rRNA complex.6

In addition to its role in RNA degradation, RNase13 is also involved in the regulation of gene expression.7 It has been shown to play a role in the regulation of gene expression by targeting specific mRNAs for degradation.8

RNase13 is also involved in DNA repair processes.9 When DNA damage occurs, RNase13 can participate in the repair process by removing damaged RNA from the damaged site.10

Potential Therapeutic Applications

The potential of RNase13 as a drug target is due to its unique structure and subcellular localization. Its subunit structure makes it a potential target for small molecules that can modulate its activity.11 Additionally, its localization in the cytoplasm and its involvement in various cellular processes make it an attractive target for drugs that can modulate its levels.

RNase13 has also been shown to be a potential biomarker for various diseases, including cancer.12 Its involvement in the regulation of gene expression and its role in DNA repair processes make it an attractive target for cancer therapies.13

Conclusion

In conclusion, RNase13 is a promising drug target and biomarker due to its unique structure and subcellular localization. Its involvement in various cellular processes makes it an attractive target for small molecules that can modulate its activity. Additionally, its potential as a biomarker for cancer therapies makes it an important target for drug development. Further research is needed to fully understand its function and potential as a drug target and biomarker.

Protein Name: Ribonuclease A Family Member 13 (inactive)

Functions: Does not exhibit any ribonuclease activity

More Common Targets

RNASE2 | RNASE2CP | RNASE3 | RNASE4 | RNASE6 | RNASE7 | RNASE8 | RNASE9 | RNASEH1 | RNASEH1-DT | RNASEH2A | RNASEH2B | RNASEH2B-AS1 | RNASEH2C | RNASEH2CP1 | RNASEK | RNASEL | RNASET2 | RND1 | RND2 | RND3 | RNF10 | RNF103 | RNF103-CHMP3 | RNF11 | RNF111 | RNF112 | RNF113A | RNF113B | RNF114 | RNF115 | RNF121 | RNF122 | RNF123 | RNF125 | RNF126 | RNF126P1 | RNF128 | RNF13 | RNF130 | RNF133 | RNF135 | RNF138 | RNF138P1 | RNF139 | RNF139-DT | RNF14 | RNF141 | RNF144A | RNF144B | RNF145 | RNF146 | RNF148 | RNF149 | RNF150 | RNF151 | RNF152 | RNF157 | RNF157-AS1 | RNF165 | RNF166 | RNF167 | RNF168 | RNF169 | RNF17 | RNF170 | RNF175 | RNF180 | RNF181 | RNF182 | RNF183 | RNF185 | RNF186 | RNF187 | RNF19A | RNF19B | RNF2 | RNF20 | RNF207 | RNF208 | RNF212 | RNF212B | RNF213 | RNF213-AS1 | RNF214 | RNF215 | RNF216 | RNF216-IT1 | RNF216P1 | RNF217 | RNF217-AS1 | RNF220 | RNF222 | RNF224 | RNF225 | RNF227 | RNF24 | RNF25 | RNF26 | RNF31