Target Name: RNASEH2A
NCBI ID: G10535
Other Name(s): Ribonuclease HI large subunit | RNASEHI | Ribonuclease H2 subunit A | RNH2A_HUMAN | ribonuclease H2 subunit A | RNHIA | ribonuclease H2, large subunit | RNase H(35) | RNHL | Rbonuclease HI, large subunit | Ribonuclease H2, large subunit | RNase H2 subunit A | aicardi-Goutieres syndrome 4 protein | Aicardi-Goutieres syndrome 4 protein | JUNB | ribonuclease HI subunit A | RNase HI large subunit | ribonuclease HI large subunit | THSD8 | Ribonuclease HI subunit A | AGS4

Unlocking the Potential of RNASEH2A: A Ribonuclease HI Large Subunit as a Drug Target and Biomarker

Ribonuclease HI (RnaseH) is a family of enzyme that plays a crucial role in the process of DNA damage repair. nRNAase HI (RnaseH2) is a subunit of RnaseH that is specifically involved in the processing of double-stranded RNA (dsRNA). RnaseH2 activity is required for DNA double-strand break repair, and it has been implicated in various diseases, including cancer, neurodegenerative diseases, and systemic inflammatory responses. As a result, targeting RnaseH2a has emerged as a promising strategy for developing therapeutic approaches for these diseases. In this article, we will explore the potential of RNASEH2a as a drug target and biomarker.

The Problem

Ribonuclease HI (RnaseH) is a enzyme that plays a crucial role in the process of DNA damage repair. DNA double-strand breaks are critical events that can lead to genetic mutations, leading to various diseases, including cancer, neurodegenerative diseases, and systemic inflammatory responses. RnaseH is involved in the processing of double-stranded RNA (dsRNA), and it has been shown to have essential roles in DNA double-strand break repair.

However, despite its crucial role in DNA damage repair, RnaseH is also involved in the process of RNA degradation, which can lead to the production of harmful RNA species that contribute to various diseases. RnaseH2, the large subunit of RnaseH, is specifically involved in the processing of double-stranded RNA (dsRNA) and has been shown to have various roles in RNA metabolism, including the regulation of gene expression, translation, and degradation.

Targeting RnaseH2a

Targeting RnaseH2a has emerged as a promising strategy for developing therapeutic approaches for various diseases. By inhibiting RnaseH2a activity, researchers can reduce the production of harmful RNA species that contribute to disease progression. In addition, targeting RnaseH2a has the potential to enhance the efficacy of existing therapeutic approaches, as it can help reduce the resistance of cancer cells to chemotherapy.

The Potential of RNASEH2a as a Drug Target

RNaseH2a has been shown to play a crucial role in the process of DNA double-strand break repair. It is involved in the recognition and cleavage of double-stranded RNA, which is critical for the repair of DNA double-strand breaks. Therefore, inhibiting RnaseH2a activity could be a promising strategy for treating diseases that are characterized by DNA double-strand break repair deficiencies.

One of the potential benefits of targeting RnaseH2a is its potential to reduce the production of harmful RNA species that contribute to disease progression. For example, RnaseH2a has been shown to participate in the regulation of gene expression and translation, which can lead to the production of various proteins that contribute to disease progression. By inhibiting RnaseH2a activity, researchers can reduce the production of these proteins and potentially reduce the risk of disease progression.

The Potential of RNaseH2a as a Biomarker

In addition to its potential as a drug target, RnaseH2a has also been shown to have potential as a biomarker. RnaseH2a has been shown to have a relatively stable expression level in various tissues and cells, which makes it a potential marker for certain diseases. For example, RnaseH2a has been shown to be downregulated in various cancer tissues compared to surrounding tissue, which could be an indication of its potential as a cancer biomarker.

Another potential use of RnaseH2a as a biomarker is its potential to monitor the effectiveness of certain therapeutic approaches. For example, if an inhibitor of

Protein Name: Ribonuclease H2 Subunit A

Functions: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes

More Common Targets

RNASEH2B | RNASEH2B-AS1 | RNASEH2C | RNASEH2CP1 | RNASEK | RNASEL | RNASET2 | RND1 | RND2 | RND3 | RNF10 | RNF103 | RNF103-CHMP3 | RNF11 | RNF111 | RNF112 | RNF113A | RNF113B | RNF114 | RNF115 | RNF121 | RNF122 | RNF123 | RNF125 | RNF126 | RNF126P1 | RNF128 | RNF13 | RNF130 | RNF133 | RNF135 | RNF138 | RNF138P1 | RNF139 | RNF139-DT | RNF14 | RNF141 | RNF144A | RNF144B | RNF145 | RNF146 | RNF148 | RNF149 | RNF150 | RNF151 | RNF152 | RNF157 | RNF157-AS1 | RNF165 | RNF166 | RNF167 | RNF168 | RNF169 | RNF17 | RNF170 | RNF175 | RNF180 | RNF181 | RNF182 | RNF183 | RNF185 | RNF186 | RNF187 | RNF19A | RNF19B | RNF2 | RNF20 | RNF207 | RNF208 | RNF212 | RNF212B | RNF213 | RNF213-AS1 | RNF214 | RNF215 | RNF216 | RNF216-IT1 | RNF216P1 | RNF217 | RNF217-AS1 | RNF220 | RNF222 | RNF224 | RNF225 | RNF227 | RNF24 | RNF25 | RNF26 | RNF31 | RNF32 | RNF32-DT | RNF34 | RNF38 | RNF39 | RNF4 | RNF40 | RNF41 | RNF43 | RNF44 | RNF5