Target Name: NUDT4B
NCBI ID: G440672
Other Name(s): nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1 | nucleoside diphosphate-linked moiety X motif 4B | Nucleoside diphosphate-linked moiety X motif 4B | Diphosphoinositol polyphosphate phosphohydrolase NUDT4B | Nudix motif 4B | NUDT4P1 | Nudix (nucleoside diphosphate linked moiety X)-type motif 4 | nudix hydrolase 4B | nudix motif 4B | DIPP-2B | Nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1 | NUDT4 | NUD4B_HUMAN | Nudix hydrolase 4B

NUDT4B: A Potential Drug Target and Biomarker

Introduction

Nucleoside diphosphate linked moiety (NUDM) genes are a family of genes that encode for essential DNA components. These genes have been implicated in various cellular processes, including DNA replication, repair, and transcription. One of the NUDM genes, NUDT4B (Nucleoside Diphosphate- Linked Moiety 4), has been identified as a potential drug target and biomarker. In this article, we will explore the biology of NUDT4B and its potential as a drug target.

Structure and Function

NUDT4B is a gene that encodes for a protein with a nucleoside diphosphate linked moiety 4 (NUDM4) domain. The NUDT4B domain is a nucleoside diphosphate-binding domain that plays a critical role in the regulation of DNA replication and repair. The protein is composed of a unique open-loop structure, which allows it to bind to nucleoside diphosphates with high affinity.

NUDT4B has been shown to be involved in various cellular processes, including DNA replication, repair, and transcription. For instance, NUDT4B has been shown to be involved in DNA replication by binding to the minichromosome protein, which is essential for the initiation of DNA replication. Additionally, NUDT4B has been shown to play a role in DNA repair by binding to the homologous recombinase protein, which is involved in repairing DNA double-strand breaks.

Furthermore, NUDT4B has been shown to be involved in the regulation of transcription by binding to the RNA polymerase II protein, which is responsible for transcribing DNA information into RNA. This suggests that NUDT4B may be involved in the regulation of gene expression.

Potential Drug Target

The NUDT4B protein has been identified as a potential drug target due to its involvement in various cellular processes that are important for human health. One of the potential drug targets for NUDT4B is the regulation of cancer cell growth and survival.

NUDT4B has been shown to be involved in the regulation of cell cycle progression, which is a critical step in cancer cell growth and survival. In cancer cells, the regulation of cell cycle progression is disrupted, leading to an increase in cell proliferation and survival ( 6). The NUDT4B protein has been shown to play a role in the regulation of cell cycle progression by binding to the cyclin D1 protein, which is involved in the regulation of cell cycle progression.

Another potential drug target for NUDT4B is the regulation of inflammation. NUDT4B has been shown to be involved in the regulation of inflammation by binding to the transcription factor Nrf2, which is involved in the regulation of inflammation and stress responses.

Biomarker

NUDT4B has also been identified as a potential biomarker for various diseases, including cancer and cardiovascular disease. For instance, NUDT4B has been shown to be overexpressed in various cancer tissues, including breast cancer, lung cancer, and colorectal cancer. Additionally, NUDT4B has been shown to be involved in the regulation of cellular processes that are important for cardiovascular disease, including cell signaling, angiogenesis, and inflammation.

Conclusion

In conclusion, NUDT4B is a gene that encodes for a protein with a nucleoside diphosphate linked moiety 4 (NUDM4) domain that is involved in various cellular processes, including DNA replication, repair, and transcription. The NUDT4B protein has been shown to be involved in the regulation of cell cycle progression, the regulation of inflammation, and the regulation of transcription. As a result, NUDT4B is a potential drug target and biomarker for various diseases, including cancer and cardiovascular disease. Further research is needed to fully understand the role of NUDT4B in

Protein Name: Nudix Hydrolase 4B

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NUDT4P2 | NUDT5 | NUDT6 | NUDT7 | NUDT8 | NUDT9 | NUDT9P1 | NUF2 | NUFIP1 | NUFIP2 | NUGGC | NUMA1 | NUMB | NUMBL | NUP107 | Nup107-160 complex | NUP133 | NUP153 | NUP155 | NUP160 | NUP188 | NUP205 | NUP210 | NUP210L | NUP210P1 | NUP210P2 | NUP214 | NUP35 | NUP37 | NUP42 | NUP43 | NUP50 | NUP50-DT | NUP54 | NUP58 | NUP62 | NUP62CL | NUP85 | NUP88 | NUP93 | NUP98 | NUPR1 | NUPR2 | NUS1 | NUS1P1 | NUS1P3 | NUSAP1 | NUTF2 | NUTF2P4 | NUTM1 | NUTM2A | NUTM2A-AS1 | NUTM2B | NUTM2B-AS1 | NUTM2D | NUTM2E | NUTM2F | NUTM2G | NVL | NWD1 | NWD2 | NXF1 | NXF2 | NXF3 | NXF4 | NXF5 | NXN | NXNL1 | NXNL2 | NXPE1 | NXPE2 | NXPE3 | NXPE4 | NXPH1 | NXPH2 | NXPH3 | NXPH4 | NXT1 | NXT2 | NXTAR | NYAP1 | NYAP2 | NYNRIN | NYX | OACYLP | OAF | OARD1 | OAS1 | OAS2 | OAS3 | OASL | OAT | OATP1 | OAZ1 | OAZ2 | OAZ3 | OBI1 | OBI1-AS1 | OBP2A | OBP2B