PGM1: A Potential Drug Target and Biomarker (G5236)

Target Name: PGM1

NCBI ID: G5236

PGM1: A Potential Drug Target and Biomarker

Phosphoglucomutase-1 (PGM1) is a enzyme that plays a crucial role in the metabolism of glucose in the body. It is a key enzyme in the glycolytic pathway, which is the first step in the breakdown of glucose to produce energy. PGM1 is highly expressed in many tissues throughout the body and is involved in the regulation of cellular metabolism, including energy metabolism, cell growth, and cell death.

PGM1 is a protein that consists of 256 amino acids and has a molecular weight of 30.9 kDa. It is a single-chain protein that contains 11 known subunits. The subunits are held together by disulfide bonds, and the protein has a characteristic Rossmann-fold structure that is unique to the catalytic domain of the enzyme.

PGM1 is highly expressed in many tissues throughout the body, including the brain, heart, muscle, liver, and kidney. It is also highly expressed in cancer tissues, which suggests that it may be involved in the regulation of cellular metabolism and the development of cancer.

In addition to its role in cellular metabolism, PGM1 is also involved in the regulation of inflammation and immune responses. It has been shown to be involved in the regulation of cytokine production and the production of pro-inflammatory cytokines. It is also involved in the regulation of cell adhesion and the maintenance of tissue structure.

As a potential drug target, PGM1 is an attractive target for researchers because of its involvement in cellular metabolism and its potential role in the regulation of many different processes in the body. It is also a good candidate for a potential therapeutic intervention because of its well-established role in the regulation of cellular metabolism and its potential role in the development of cancer.

PGM1 is also a potential biomarker for the diagnosis and monitoring of many different diseases. For example, it is often used as a marker for the diagnosis of cancer, as it is highly expressed in cancer tissues and has been shown to be involved in the regulation of cellular metabolism in cancer cells. It is also used as a biomarker for many other diseases, including cardiovascular disease, neurodegenerative diseases, and autoimmune diseases.

In conclusion, PGM1 is a highly expressed enzyme that plays a crucial role in the metabolism of glucose in the body. It is also involved in the regulation of cellular metabolism, inflammation, and immune responses, making it an attractive target for researchers and potential therapeutic intervention. Further research is needed to fully understand the role of PGM1 in cellular metabolism and its potential as a drug target and biomarker.

Protein Name: Phosphoglucomutase 1

Functions: This enzyme participates in both the breakdown and synthesis of glucose

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