PHACTR3: Key Regulator of Cell-Cell Signaling and Cell Migration

Target Name: PHACTR3

NCBI ID: G116154

PHACTR3: Key Regulator of Cell-Cell Signaling and Cell Migration

PHACTR3 (short for PHosphatidylserine Aspartate Tristrammerin) is a protein that is expressed in various tissues throughout the body. It is a key regulator of cell-cell signaling, particularly in the regulation of cell adhesion and migration.

PHACTR3 is a transmembrane protein that is composed of four distinct domains: an extracellular domain, a transmembrane domain, an intracellular domain, and a C-terminal tail. The extracellular domain is responsible for the protein's ability to interact with various cell surface receptors, while the transmembrane domain is responsible for the regulation of the protein's localization and interactions within the cell membrane.

The intracellular domain is the region of the protein that interacts with other cellular components, including various signaling molecules and other proteins. This domain is known to play a role in the regulation of cellular processes such as cell growth, apoptosis, and inflammation.

PHACTR3 is a well-documented protein with several key functions. One of its most well-known functions is its role in cell adhesion. PHACTR3 is known to interact with the protein cadherin, which is a cell adhesion molecule that plays a critical role in the regulation of cell-cell signaling. This interaction between PHACTR3 and cadherin allows the protein to regulate the formation and maintenance of tight junctions, which are a type of cell-cell adhesion that is essential for various physiological processes, including cell signaling and tissue structure.

Another function of PHACTR3 is its role in cell migration. PHACTR3 is known to interact with the protein vimentin, which is a cytoskeleton protein that plays a critical role in the regulation of cell shape and movement. This interaction between PHACTR3 and vimentin allows the protein to regulate the formation and maintenance of cellular structures that contribute to cell migration.

PHACTR3 is also involved in the regulation of cell apoptosis, which is the process by which cells undergo programmed cell death. The intracellular domain of PHACTR3 is known to play a role in the regulation of cell apoptosis, with studies showing that the protein can interact with the protein Bcl-2 and that it may be a negative regulator of the Bcl-2 gene. This suggests that PHACTR3 may play a role in the regulation of cell life and death.

Finally, PHACTR3 is also involved in the regulation of inflammation. The transmembrane domain of PHACTR3 is known to interact with various signaling molecules, including the protein TNF-alpha and the cytokine interleukin-1. This interaction between PHACTR3 and these molecules allows the protein to regulate the regulation of cellular responses to inflammation.

In conclusion, PHACTR3 is a well-documented protein that is involved in a variety of cellular processes. Its functions include cell adhesion, migration, apoptosis, and inflammation. As a potential drug target or biomarker, PHACTR3 is a promising target for the development of new therapies for a variety of diseases.

Protein Name: Phosphatase And Actin Regulator 3

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