PHB2: A Potential Drug Target and Biomarker (G11331)

Target Name: PHB2

NCBI ID: G11331

PHB2: A Potential Drug Target and Biomarker

PHB2, also known as Prohibitin 2 or Transcript Variant 1, is a protein that is expressed in various tissues throughout the body. It is a member of the inhibitor of DNA binding (IDB) family, which is known for its role in regulating gene expression and DNA replication.

PHB2 has been identified as a potential drug target due to its involvement in the regulation of cell growth, apoptosis, and inflammation. The IDB family has been shown to play a role in the regulation of cell growth by inhibiting the activity of the oncogene transforming growth factor-beta (TGF-beta), which is a key regulator of cell growth and differentiation.

PHB2 has also been shown to play a role in the regulation of apoptosis, which is the process by which cells undergo programmed cell death. In addition, PHB2 has been shown to be involved in the regulation of inflammation, which is a critical immune response to infection and disease.

PHB2 is expressed in various tissues throughout the body, including the brain, spleen, and lymphoid organs. It is also expressed in various cell types, including cancer cells, stem cells, and immune cells.

PHB2 has been shown to play a role in the regulation of cell growth and apoptosis in various organisms, including humans. For example, studies have shown that PHB2 is involved in the regulation of cell growth and apoptosis in cancer cells. In addition, PHB2 has been shown to play a role in the regulation of apoptosis in stem cells, which are cells that have the ability to develop into different cell types.

PHB2 is also involved in the regulation of inflammation in various organisms. For example, studies have shown that PHB2 is involved in the regulation of inflammation in response to infection and disease.

In addition to its potential as a drug target, PHB2 has also been shown to have potential as a biomarker for various diseases. For example, studies have shown that PHB2 is involved in the regulation of cancer progression, and that it may be a useful biomarker for cancer diagnosis and treatment.

Overall, PHB2 is a protein that has potential as a drug target and biomarker due to its involvement in the regulation of cell growth, apoptosis, and inflammation. Further research is needed to fully understand its role in these processes and its potential as a drug.

Protein Name: Prohibitin 2

Functions: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus

More Common Targets