PHF12: Key Protein in Cell Division and Disease (G57649)

Target Name: PHF12

NCBI ID: G57649

PHF12: Key Protein in Cell Division and Disease

PHF12, also known as PHD factor 1, is a protein that is found in the blood of all humans. It is a key factor in the process of cell division, and is often used as a drug target or biomarker for various diseases.

PHF12 plays a crucial role in the development and maintenance of normal cell division. During cell division, PHF12 helps to ensure that the cell divides correctly and that the new cell has the same number of chromosomes as the original cell. If something goes wrong during this process, it can lead to the development of a variety of diseases, including cancer.

One of the key functions of PHF12 is its role in the telomere. Telomeres are the protective caps at the end of chromosomes that help to prevent chromosomes from deteriorating or fusing with one another. PHF12 helps to protect telomeres by ensuring that they are properly maintained and that they are not damaged during the process of cell division.

Another important function of PHF12 is its role in the process of apoptosis. Apoptosis is the process by which cells die, and it is a natural and important part of the immune system. PHF12 helps to ensure that apoptosis occurs properly and that it is not abnormal , which can lead to the development of diseases.

PHF12 is also a potential drug target for several diseases, including cancer. Cancer is a disease that can be caused by a variety of factors, including genetic mutations, abnormal cell division, and inflammation. Many drugs that are currently used to treat cancer work by targeting PHF12 and inhibiting its function.

In addition to its role as a drug target, PHF12 is also a potential biomarker for several diseases. By measuring the levels of PHF12 in blood, doctors can get a sense of how well a patient is responding to a particular treatment and identify the presence of any potential side effects. This can be important for patients with cancer, as accurate measurements of PHF12 levels can help doctors to determine the effectiveness of a particular treatment and make any necessary adjustments.

Overall, PHF12 is a protein that plays a critical role in the process of cell division and the development of diseases. It is an important drug target and biomarker, and its proper function is essential for maintaining the health and well-being of the body.

Protein Name: PHD Finger Protein 12

Functions: Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA

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