Discovering The Potential of NLRC4 as A Drug Target Or Biomarker

Target Name: NLRC4

NCBI ID: G58484

Discovering The Potential of NLRC4 as A Drug Target Or Biomarker

NLRC4 (CLANA) is a protein that is expressed in various tissues throughout the body, including the brain, spleen, and pancreas. It is a member of the long non-coding RNA (lncRNA) family, which includes proteins that play important roles in various cellular processes. One of the functions of NLRC4 is to regulate the expression of other genes, and it is thought to be involved in the development and progression of certain diseases.

Recent studies have suggested that NLRC4 may have potential as a drug target or biomarker. For example, some researchers have found that high levels of NLRC4 expression are associated with poor prognosis in pancreatic cancer, and that inhibiting NLRC4 may be an effective way to treat this disease. Additionally, some studies have suggested that NLRC4 may be involved in the development of other diseases, such as neurodegenerative disorders and cancer.

In addition to its potential as a drug target or biomarker, NLRC4 is also of interest to researchers because of its unique structure and biology. NLRC4 is a transmembrane protein that is composed of a variable number of exons, which means that it may have different functions depending on the cell type and the context in which it is expressed. This makes it difficult to predict how NLRC4 will behave in different settings and how it might be able to interact with other proteins.

Overall, while NLRC4 is still a relatively little-known protein, its potential as a drug target or biomarker is exciting to researchers. As more studies are conducted to understand its biology and function, it is likely that we will find more ways to use NLRC4 to treat and prevent disease.

Protein Name: NLR Family CARD Domain Containing 4

Functions: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity)

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