CENPK: A Potential Drug Target and Biomarker for Centromere Complex Protein 37

Target Name: CENPK

NCBI ID: G64105

CENPK: A Potential Drug Target and Biomarker for Centromere Complex Protein 37

Introduction

Centromere complex (CC) proteins play a crucial role in the proper formation of chromosomes during cell division. One of the CC proteins, CENPK (interphase centromere complex protein 37), has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and developmental disorders. This article will provide an overview of CENPK, its functions, potential drug targets, and potential use as a biomarker.

Overview of CENPK

CENPK is a 21-kDa protein that belongs to the CC family of proteins. It is a key component of the CC complex, which is responsible for organizing the chromosomes during the process of cell division. CENPK plays a critical role in the regulation of the cohesion of sister chromatids at the centromere, which is the region of the chromosome where the sister chromatids co-adjust to the diploid state.

functions

CENPK has several critical functions in the CC complex, including:

1.Regulation of sister chromatid cohesion: CENPK forms a complex with the protein cohesion-promoting complex (CPC), which helps to regulate the cohesion of sister chromatids at the centromere.

2.Chromatin remodeling: CENPK is involved in the remodeling of chromatin structure at the centromere. It helps to ensure the proper organization of chromatin during the process of cell division.

3.Drug resistance: CENPK has been shown to contribute to the drug resistance of cancer cells. This is because of its role in the regulation of cell division, which is critical for the development of drug resistance in cancer cells.

Potential Drug Targets

CENPK has been identified as a potential drug target for various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

1. Cancer: CENPK has been shown to promote the growth and survival of cancer cells. This is because of its role in the regulation of cell division and the regulation of the expression of genes involved in cancer.

2. Neurodegenerative diseases: CENPK has been shown to contribute to the development and progression of neurodegenerative diseases. This is because of its role in the regulation of the expression of genes involved in neurodegenerative diseases.

3. Developmental disorders: CENPK has been shown to contribute to the development and progression of developmental disorders. This is because of its role in the regulation of the expression of genes involved in developmental disorders.

Potential Biomarkers

CENPK has also been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

1. Cancer: CENPK has been shown to be a potential biomarker for cancer. This is because of its role in the regulation of cell division and the regulation of the expression of genes involved in cancer.

2. Neurodegenerative diseases: CENPK has been shown to be a potential biomarker for neurodegenerative diseases. This is because of its role in the regulation of the expression of genes involved in neurodegenerative diseases.

3. Developmental disorders: CENPK has been shown to be a potential biomarker for developmental disorders. This is because of its role in the regulation of the expression of genes involved in developmental disorders.

Conclusion

In conclusion, CENPK is a protein that plays a critical role in the CC complex and has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Further research is needed to fully understand the functions of CENPK and its potential as a drug

Protein Name: Centromere Protein K

Functions: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore

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