Unlocking the Potential of CEP135: A Potential Drug Target and Biomarker

Target Name: CEP135

NCBI ID: G9662

Unlocking the Potential of CEP135: A Potential Drug Target and Biomarker

Introduction

Centrosomes are essential cellular structures that play a crucial role in the proper functioning of cells. They are dynamic organelles that mediate the assembly, disassembly, and organization of chromosomes during cell division and meiosis. One of the key proteins involved in the assembly and disassembly of centrosomes is CEP135, a protein that has been identified as a potential drug target and biomarker.

CEP135: A Protein of High Interest

CEP135 is a 21-kDa protein that is expressed in a variety of tissues, including brain, heart, liver, and muscle. It is a member of the centrosome subfamily and is involved in the assembly and disassembly of centrosomes. CEP135 has been shown to play a critical role in the regulation of cell division and meiosis.

During cell division, CEP135 is involved in the formation and stability of the centrosome. It helps to ensure that the correct number of chromosomes are replicated and that the centrosome is properly organized before the daughter cells divide. During meiosis, CEP135 is involved in the formation of the karyotic spindle, which is responsible for ensuring the proper separation of chromosomes during cell division.

In addition to its role in cell division and meiosis, CEP135 has also been shown to play a potential drug target. Its unique structure and subcellular localization make it an attractive target for small molecules. Furthermore, its involvement in the regulation of cell division and meiosis make it an attractive biomarker for the diagnosis and treatment of various diseases.

CEP135 as a Drug Target

The potential of CEP135 as a drug target is due to its unique structure and subcellular localization. CEP135 is a protein that is expressed in a variety of tissues and has been shown to localize to the centrosome and the endoplasmic reticulum. This localization makes it an attractive target for small molecules that can modulate its activity.

One of the key challenges in developing a drug target for CEP135 is its subcellular localization. Despite its localization to the centrosome and endoplasmic reticulum, CEP135 is not well understood, and it is not clear how it interacts with other cellular structures. To overcome this challenge , researchers have used a variety of techniques, including biochemical, cellular, and structural studies, to gain a better understanding of CEP135's subcellular localization and its potential targets.

In addition to its subcellular localization, CEP135's unique structure and protein level also make it an attractive target for small molecules. Its high protein level and the fact that it is involved in the regulation of cell division and meiosis make it an attractive target for small molecules. that can modulate its activity.

CEP135 as a Biomarker

The potential of CEP135 as a biomarker is due to its involvement in the regulation of cell division and meiosis. During cell division, CEP135 plays a critical role in the formation and stability of the centrosome. During meiosis, CEP135 is involved in the formation of the karyotic spindle, which is responsible for ensuring the proper separation of chromosomes during cell division.

In addition to its role in cell division and meiosis, CEP135 has also been shown to play a potential biomarker in various diseases. For example, studies have shown that changes in CEP135 levels can be associated with the development of certain diseases, such as cancer. Additionally, CEP135 has been shown to play a critical role in

Protein Name: Centrosomal Protein 135

Functions: Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865)

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