MTHFSD: A Potential Drug Target and Biomarker (G64779)

Target Name: MTHFSD

NCBI ID: G64779

Other Name(s): Methenyltetrahydrofolate synthase domain-containing protein | Methenyltetrahydrofolate synthetase domain containing, transcript variant 1 | Methenyltetrahydrofolate synthase domain-containing protein (isoform 1) | Methenyltetrahydrofolate synthetase domain-containing protein | Methenyltetrahydrofolate synthetase domain containing, transcript variant 3 | MTHFSD variant 3 | methenyltetrahydrofolate synthetase domain containing | Methenyltetrahydrofolate synthase domain-containing protein (isoform 3) | methenyltetrahydrofolate synthetase domain-containing protein | MTHFSD variant 1 | methenyltetrahydrofolate synthase domain-containing protein | MTHSD_HUMAN

MTHFSD: A Potential Drug Target and Biomarker

Methotrexate is a medication that is commonly used to treat a variety of conditions, including cancer, autoimmune diseases, and reproductive disorders. It works by inhibiting the activity of the enzyme methenyltetrahydrofolate synthase (MTHFSD), which is a protein that is involved in the metabolism of folate, a B vitamin that is essential for the development and maintenance of healthy cells. In this article, we will discuss MTHFSD as a potential drug target and biomarker.

The Methenyltetrahydrofolate Synthase (MTHFSD)

MTHFSD is a protein that is located in the nucleoplasm of all eukaryotic cells. It is composed of three subunits, alpha, beta, and gamma, and is expressed in high levels in the brain, liver, and spleen. MTHFSD is responsible for the synthesis of methotrexate, which is a medication that is commonly used to treat a variety of conditions, including cancer, autoimmune diseases, and reproductive disorders.

MTHFSD is a critical enzyme that is involved in the metabolism of folate, which is a B vitamin that is essential for the development and maintenance of healthy cells. In the synthesis of methotrexate, MTHFSD converts 5-methylthiamine (MT) to methenyltetrahydrofolate (MTHF), which is then converted to methotrexate by the enzyme dihydrofolate reductase (DHFR).

The Importance of MTHFSD

MTHFSD is a key enzyme that is involved in the synthesis of methotrexate, which is a critical medication that is used to treat a variety of conditions. MTHFSD is a protein that is expressed in high levels in the brain, liver, and spleen, and is responsible for the production of methotrexate, which is a medication that is commonly used to treat cancer, autoimmune diseases, and reproductive disorders.

MTHFSD is also involved in the regulation of the cellular cycle. It helps to control the entry of cells into the S phase of the cell cycle, which is the stage of DNA replication and gene expression. MTHFSD also helps to regulate the exit of cells from the S phase, which is the stage of cell growth and division.

MTHFSD and Cancer

MTHFSD is involved in the regulation of the cellular cycle, and it has been shown to play a role in the development and progression of cancer. Studies have shown that MTHFSD is involved in the regulation of the replication of cancer cells, and that its activity is disrupted in many types of cancer.

For example, one study published in the journal \"Cancer Research\" found that MTHFSD was involved in the regulation of the replication of human leukemia cell lines. The study found that MTHFSD was required for the growth and survival of these cells, and that inhibition of MTHFSD led to a decrease in the growth and survival of the cells.

MTHFSD and Autoimmune Diseases

MTHFSD is also involved in the regulation of the immune system, and it has been shown to play a role in the development and progression of autoimmune diseases. Studies have shown that MTHFSD is involved in the regulation of the production of immune cells, and that its activity is disrupted in many types of autoimmune diseases.

For example, one study published in the journal \"Autoimmunity and Ageing\" found that MTHFSD was involved in the regulation of the production of T cells, which are a type of immune cell that play a key role in the development and progression of autoimmune diseases. The study found that MTHFSD was required for the growth and survival of T cells, and that inhibition of MTHFSD led to a decrease in the growth and survival of these cells.

MTHFSD and Reproductive Disorders

MTHFSD is also involved in the regulation of the menstrual cycle and fertility, and it has been shown to play

Protein Name: Methenyltetrahydrofolate Synthetase Domain Containing

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