TAF6: A Potential Drug Target Or Biomarker (G6878)

Target Name: TAF6

NCBI ID: G6878

TAF6: A Potential Drug Target Or Biomarker

TAF6 (MGC:8964) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the TAF6 family, which is characterized by the presence of a unique nucleotide sequence at its C-terminus.

The TAF6 protein is of interest as a potential drug target or biomarker due to its involvement in several cellular processes that are important for human health. One of the most significant functions of TAF6 is its role in the regulation of cell death, which is a critical process that helps maintain tissue homeostasis and ensure the survival of cells.

TAF6 is known to be involved in the formation of apoptotic cells, which are cells that undergo programmed cell death. This process is important for the development and progression of many diseases, including cancer, neurodegenerative disorders, and diseases that affect the immune system.

In addition to its role in cell death, TAF6 is also involved in the regulation of cell proliferation, which is the process by which cells grow and divide. This process is important for the development and maintenance of tissues and organs, and is also important for the growth and development of cancer.

TAF6 is also involved in the regulation of cellular signaling pathways, which are the processes by which cells communicate with one another to carry out various functions. This includes the regulation of angiogenesis, the process by which new blood vessels are formed, and the regulation of immune responses.

TAF6 is also of interest as a potential biomarker due to its expression in a wide range of tissues and its ability to be targeted with small molecules. This makes it a promising candidate for use as a drug or diagnostic agent.

In conclusion, TAF6 is a protein that is of interest as a potential drug target or biomarker due to its involvement in several cellular processes that are important for human health. Further research is needed to fully understand the role of TAF6 in these processes and its potential as a drug or diagnostic agent.

Protein Name: TATA-box Binding Protein Associated Factor 6

Functions: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473)

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