TAF12: A Protein with Potential as A Drug Target Or Biomarker

Target Name: TAF12

NCBI ID: G6883

TAF12: A Protein with Potential as A Drug Target Or Biomarker

TAF12 (TAF15) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the TAF12 family, which includes several similar proteins that are involved in various cellular processes, including cell signaling and inflammation.

Recent studies have suggested that TAF12 may have potential as a drug target or biomarker. One of the main reasons for this is the fact that TAF12 is involved in several important cellular processes that are affected by various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

For example, TAF12 has been shown to be involved in the regulation of cell signaling pathways that are involved in cancer growth and progression. In addition, TAF12 has been shown to play a role in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Another potential mechanism by which TAF12 may be involved in these diseases is its role in modulating the immune response. TAF12 has been shown to be involved in the regulation of immune cell function and has been implicated in the development of autoimmune disorders.

In addition to its potential as a drug target or biomarker, TAF12 is also of interest as a potential therapeutic agent for a variety of diseases. For example, TAF12 has been shown to be involved in the regulation of cell signaling pathways that are involved in pain perception and neuroinflammation. This suggests that TAF12 may be a useful agent for the treatment of pain and neuroinflammation disorders.

Overall, TAF12 is a protein that is of interest as a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand its role in these processes and to determine its potential as a therapeutic agent.

Protein Name: TATA-box Binding Protein Associated Factor 12

Functions: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:7729427, PubMed:8598932, PubMed:8663456, PubMed:9674425, PubMed:9885574)

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