TAF5L: A Potential Drug Target and Biomarker for PCAF-Associated Factor 65 Beta

Target Name: TAF5L

NCBI ID: G27097

Other Name(s): PCAF associated factor 65 beta | TATA-box binding protein associated factor 5 like, transcript variant 1 | PAF65-beta | PAF65B | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (isoform a) | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa | TATA-box binding protein associated factor 5 like | TAF5L_HUMAN | TAF5L variant 1 | PCAF-associated factor 65 beta

TAF5L: A Potential Drug Target and Biomarker for PCAF-Associated Factor 65 Beta

Abstract:

PCAF-Associated Factor 65 (PCAF65) is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer. The PCAF family is composed of four isoforms, PCAF1, PCAF2, PCAF3, and PCAF4, of which PCAF65 is the most abundant isoform. PCAF65 has been shown to play a critical role in various cellular processes, including cell signaling, DNA replication, and apoptosis. The identification of PCAF65 as a potential drug target and biomarker has led to a growing body of research aimed at understanding its role in human disease and developing new treatments.

Introduction:

PCAF-Associated Factor 65 (PCAF65) is a protein that is expressed in various cell types and has been shown to play a critical role in various cellular processes. PCAF65 has been shown to be involved in cell signaling, DNA replication, and apoptosis. Its functions have led it to be considered as a potential drug target and biomarker for various diseases.

PCAF65 has been shown to play a critical role in cell signaling, where it is involved in the regulation of cell proliferation and differentiation. PCAF65 has been shown to play a role in the regulation of cell cycle progression, where it promotes the G1 phase and inhibits the S phase. This is important for cell signaling and has implications for the development of cancer.

PCAF65 has also been shown to play a critical role in DNA replication. PCAF65 has been shown to be involved in the regulation of DNA replication, where it helps ensure that the DNA replication process is accurate and efficient. This is important for the development and progression of cancer.

PCAF65 has also been shown to play a critical role in apoptosis. PCAF65 has been shown to play a role in the regulation of apoptosis, where it helps ensure that cells undergo programmed cell death. This is important for the development and progression of cancer.

In addition to its role in cell signaling, PCAF65 has also been shown to play a critical role in the regulation of inflammation. PCAF65 has been shown to play a role in the regulation of inflammation, where it helps to control the immune response.

PCAF65 has also been shown to play a critical role in the regulation of cellular processes that are important for the development and progression of cancer. For example, PCAF65 has also been shown to play a role in the regulation of cell adhesion, where it helps to ensure that cells stick together and form tissues. This is important for the development and progression of cancer.

PCAF65 has also been shown to play a critical role in the regulation of the cytoskeleton. PCAF65 has also been shown to play a role in the regulation of the cytoskeleton, where it helps to maintain the shape and stability of cells. This is important for the development and progression of cancer.

In conclusion, PCAF65 is a protein that has been shown to play a critical role in various cellular processes, including cell signaling, DNA replication, apoptosis, inflammation, and cytoskeleton. Its functions have led it to be considered as a potential drug target and biomarker for various diseases.

Drug Targets:

PCAF65 has been identified as a potential drug target due to its involvement in various cellular processes that are important for the development and progression of cancer. For example, PCAF

Protein Name: TATA-box Binding Protein Associated Factor 5 Like

Functions: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity)

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