TLR5 Regulates Innate Immune Response and Cellular Signaling Pathways

Target Name: TLR5

NCBI ID: G7100

TLR5 Regulates Innate Immune Response and Cellular Signaling Pathways

Toll-like receptor 5 (TLR5) is a protein that is expressed in many different tissues throughout the body. It is a key mediator of the innate immune response, which is the body's first line of defense against infection. TLR5 is a G protein-coupled receptor (GPCR), which means that it consists of a extracellular domain that is held by a protein called G protein, which is then terminated by a C-terminal intracellular domain.

TLR5 is involved in a wide range of physiological processes in the body, including inflammation, infection, and response to stress. It is a critical receptor for the activation of the innate immune response, which is the body's first line of defense against infection. TLR5 recognizes specific DNA sequences that are present in the cytoplasm of cells, which are derived from microbial pathogens.

TLR5 is also involved in the regulation of cellular signaling pathways that are important for tissue growth, development, and differentiation. It is a negative regulator of the TGF-β pathway, which is a well-known signaling pathway that is involved in the regulation of cellular growth and differentiation. TLR5 promotes the negative role of TGF-β by regulating the activity of the transcription factor, Smad.

TLR5 is also involved in the regulation of inflammation. It is a critical receptor for the activation of the complement system, which is a group of proteins that work together to help eliminate pathogens from the body. TLR5 recognizes specific DNA sequences that are present in the cytoplasm of cells, which are derived from microbial pathogens.

TLR5 is also involved in the regulation of cellular signaling pathways that are important for tissue repair and regeneration. It is a positive regulator of the Wnt pathway, which is a well-known signaling pathway that is involved in the regulation of cell behavior and growth. TLR5 promotes the positive role of Wnt by regulating the activity of the transcription factor, Fli1.

TLR5 is also involved in the regulation of cellular signaling pathways that are important for cell survival and longevity. It is a negative regulator of the p53 pathway, which is a well-known signaling pathway that is involved in the regulation of cell behavior and growth. TLR5 promotes the negative role of p53 by regulating the activity of the transcription factor, p53.

TLR5 is also involved in the regulation of cellular signaling pathways that are important for cell-cell communication and tissue organization. It is a negative regulator of the Notch pathway, which is a well-known signaling pathway that is involved in the regulation of cell behavior and growth. TLR5 promotes the negative role of Notch by regulating the activity of the transcription factor, Jagged.

TLR5 is also involved in the regulation of cellular signaling pathways that are important for cell adhesion and tissue organization. It is a positive regulator of the E-cadherin gene, which is a well-known gene that is involved in the regulation of cell adhesion. TLR5 promotes the positive role of E-cadherin by regulating the activity of the transcription factor, Snail.

TLR5 is also involved in the regulation of cellular signaling pathways that are important for cell survival and longevity. It is a negative regulator of the p21 pathway, which is a well-known signaling pathway that is involved in the regulation of cell behavior and growth. TLR5 promotes the negative role of p21 by regulating the activity of the transcription factor, p21.

TLR5 is also involved in the regulation of cellular signaling pathways that are important for cell signaling and development. It is a positive regulator of the Retinoblastoma gene, which is a well-known gene that is involved in the regulation of cell signaling and development. TLR5 promotes the positive role of Retinoblastoma by regulating the activity of the transcription factor, p50.

TLR5 is also involved in the regulation of cellular signaling pathways that are important for cell signaling and development. It is a negative regulator of the

Protein Name: Toll Like Receptor 5

Functions: Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity)

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