NPIPB11: A Protein Modulating P53 and NF-Kappa B (G728888)

Target Name: NPIPB11

NCBI ID: G728888

NPIPB11: A Protein Modulating P53 and NF-Kappa B

NPIPB11, also known as Pps22-1 protein, is a protein that is expressed in various tissues throughout the body. It is a member of the Psl family of proteins, which are known for their role in intracellular signaling. NPIPB11 has been shown to play a role in the regulation of cell growth, differentiation, and survival.

One of the key functions of NPIPB11 is its ability to interact with and modulate the activity of the transcription factor, p53. p53 is a well-known protein that plays a critical role in the regulation of gene expression and cell growth. It is capable of activating or inhibiting the activity of various target genes, depending on the context in which it is encountered.

Studies have shown that NPIPB11 can modulate the activity of p53 in a variety of ways. For example, research has shown that whenNPIPB11 is expressed in cancer cells, it can inhibit the activity of p53, leading to the activation of genes that promote cell growth and survival. This is thought to contribute to the development and progression of cancer.

Another function of NPIPB11 is its ability to interact with and modulate the activity of the transcription factor, nuclear factor kappa B (NF-kappa-B). NF-kappa-B is a protein that plays a critical role in the regulation of inflammation, immune response, and cell survival. It is composed of two subunits, p65 and p50, which can interact with each other and with various DNA-binding proteins to regulate the activity of NF-kappa-B.

Research has shown that NPIPB11 can interact with and modulate the activity of both p53 and NF-kappa-B. This interaction between NPIPB11 and these transcription factors is thought to be involved in the regulation of various cellular processes, including cell growth, differentiation, and survival.

In addition to its role in modulating the activity of p53 and NF-kappa-B, NPIPB11 has also been shown to play a role in the regulation of cell adhesion. Cell adhesion is the process by which cells stick together and form tissues. It is an important process for the development and maintenance of tissues and organs, and is also involved in the regulation of various physiological processes, including embryonic development and tissue repair.

Research has shown that NPIPB11 can modulate the activity of the adhesion molecule, E-cadherin. E-cadherin is a transmembrane protein that is involved in cell-cell adhesion. It is composed of two extracellular domains, a cytoplasmic tail and a transmembrane domain.

In conclusion, NPIPB11 is a protein that is involved in a variety of cellular processes, including cell growth, differentiation, and survival. Its interaction with transcription factors, p53 and NF-kappa-B, as well as its role in cell adhesion, makes it a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of NPIPB11 in these processes and to develop effective treatments.

Protein Name: Nuclear Pore Complex Interacting Protein Family Member B11

More Common Targets