TNFRSF4: A Potential Drug Target for Fibrosis and Cancer (G7293)

Target Name: TNFRSF4

NCBI ID: G7293

TNFRSF4: A Potential Drug Target for Fibrosis and Cancer

TNFRSF4 (Tax-transcriptionally activated glycoprotein 1 receptor) is a protein that is expressed in various tissues throughout the body, including the liver, muscle, and heart. It is a member of the TNF receptor family, which is a family of cytokines that play a crucial role in the immune system and other physiological processes.

The TNFRSF4 protein is involved in the regulation of cellular processes that are important for tissue repair and regeneration, such as inflammation, fibrosis, and cellular signaling. It is also involved in the regulation of cell survival and the cytoskeleton, which is the structure that organizes cells.

One of the key functions of TNFRSF4 is its role in the regulation of cell signaling pathways. It is a negative regulator of the PI3K/Akt signaling pathway, which is involved in the regulation of cellular processes that are important for cell survival and proliferation. This means that when TNFRSF4 is activated, it can inhibit the activity of the PI3K/Akt signaling pathway, which can lead to the inhibition of cell proliferation and survival.

Another function of TNFRSF4 is its role in the regulation of inflammation. It is involved in the regulation of the production and response to inflammatory cytokines, which are important for the regulation of immune responses and tissue repair. This means that when TNFRSF4 is activated, it can regulate the production of pro-inflammatory cytokines and can also inhibit the production of anti-inflammatory cytokines.

In addition to its role in cell signaling pathways, TNFRSF4 is also involved in the regulation of cellular cytoskeleton. It is a member of the calbindin gene family, which is involved in the regulation of cellular processes that are important for cytoskeleton organization and stability. This means that when TNFRSF4 is activated, it can regulate the organization and stability of the cytoskeleton, which can lead to the regulation of cell shape and movement.

Given its involvement in a wide range of cellular processes, TNFRSF4 is a potential drug target. Researchers are currently working to develop drugs that can specifically target TNFRSF4 and modulate its activity. These drugs have the potential to be used for a variety of therapeutic applications, including the treatment of a wide range of diseases, including cancer, fibrosis, and cardiovascular disease.

In conclusion, TNFRSF4 is a protein that is involved in a wide range of cellular processes that are important for tissue repair and regeneration. It is a member of the TNF receptor family and is involved in the regulation of cell signaling pathways, inflammation, and cytoskeleton organization. As a result, it is a potential drug target with the potential to be used for the treatment of a wide range of diseases.

Protein Name: TNF Receptor Superfamily Member 4

Functions: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity

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