Target Name: ZNF143
NCBI ID: G7702
Other Name(s): SPH-binding factor | pHZ-1 | transcriptional activator Staf | zinc finger protein 143 | Zinc finger protein 143, transcript variant 1 | selenocysteine tRNA gene transcription-activating factor | hStaf | SBF | Selenocysteine tRNA gene transcription-activating factor | Zinc finger protein 143 (isoform 1) | STAF | Transcriptional activator Staf | ZN143_HUMAN | Zinc finger protein 143 | ZNF143 variant 1

ZNF143: A Potential Drug Target and Biomarker for the Treatment ofSPH-Binding Factor-Driven Diseases

SPH-binding factor (SBF) is a protein that plays a crucial role in the regulation of cell signaling pathways, including the TGF-β pathway. This pathway is involved in the development and maintenance of tissues, and it is often aberrantly activated in diseases such as cancer, neurodegenerative diseases, and autoimmune disorders. The discovery of new potential drug targets and biomarkers for the regulation of SBF-driven diseases has the potential to improve treatment outcomes and patient outcomes. ZNF143 is a gene that has been identified as a potential drug target and biomarker for the treatment of SBF-driven diseases.

The ZNF143 Gene

ZNF143 is a gene that encodes a protein known as ZNF143. ZNF143 is a member of the ZNF family, which includes proteins that play a crucial role in the regulation of SBF-driven diseases. The ZNF family of proteins are involved in the regulation of cell signaling pathways, including the TGF-β pathway. This pathway is involved in the development and maintenance of tissues, and it is often aberrantly activated in diseases such as cancer, neurodegenerative diseases, and autoimmune disorders.

The ZNF143 Protein

ZNF143 is a protein that is expressed in a variety of tissues and cells, including human tissues and organs, mouse tissues and organs, and rat tissues and organs. ZNF143 has been shown to play a role in the regulation of the TGF-β pathway. This pathway is involved in the development and maintenance of tissues, and it is often aberrantly activated in diseases such as cancer, neurodegenerative diseases, and autoimmune disorders.

ZNF143 has been shown to interact with the protein SMAD2, which is a negative regulator of the TGF-β pathway. This interaction between ZNF143 and SMAD2 suggests that ZNF143 may be a negative regulator of the TGF-β pathway. ZNF143 has also been shown to interact with the protein FGF1, which is a regulator of the TGF-β pathway. This interaction between ZNF143 and FGF1 suggests that ZNF143 may be a positive regulator of the TGF-β pathway.

Drug Targeting ZNF143

The potential drug targeting of ZNF143 is based on its role as a negative regulator of the TGF-β pathway. The TGF-β pathway is involved in the development and maintenance of tissues, and it is often aberrantly activated in diseases such as cancer, neurodegenerative diseases, and autoimmune disorders. Therefore, drugs that can inhibit the TGF-β pathway may be effective in treating these diseases.

ZNF143 has been shown to interact with the protein SMAD2, which is a negative regulator of the TGF-β pathway. Therefore, drugs that can inhibit the interaction between ZNF143 and SMAD2 may be effective in treating diseases that are caused by the over-active TGF-β pathway.

Biomarker Development

The development of biomarkers for the diagnosis and monitoring of diseases can improve treatment outcomes and patient outcomes. The discovery of new biomarkers for the regulation of SBF-driven diseases has the potential to improve the accuracy and sensitivity of diagnostic tests and to monitor disease progress.

ZNF143 has been shown to play a role in the regulation of the TGF-β pathway, which is involved in the development and maintenance of tissues. Therefore, ZNF143 may be a useful biomarker for

Protein Name: Zinc Finger Protein 143

Functions: Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8

More Common Targets

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