SF3A2: A Protein with Unique Functions and Potential as A Drug Target

Target Name: SF3A2

NCBI ID: G8175

SF3A2: A Protein with Unique Functions and Potential as A Drug Target

SF3A2 (PRP11) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the protamine gene family, which is known for the production of proteins involved in the production of nucleosomes, a structure that is important for the organization of DNA in cells.

One of the unique features of SF3A2 is its ability to interact with other proteins, particularly the protein known as histone H3. Histone H3 is a protein that is derived from the histone group of proteins, which are responsible for the structure and stability of chromosomes.

SF3A2 has been shown to play a role in the regulation of chromatin structure and the expression of genes. It has been shown to interact with histone H3 and to help regulate the level of histone H3 in the nucleosome. This interaction between SF3A2 and histone H3 is important for the proper functioning of the chromatin structure and the regulation of gene expression.

In addition to its role in chromatin regulation, SF3A2 has also been shown to play a role in the regulation of cellular processes that are important for the survival and growth of cells. For example, it has been shown to be involved in the regulation of cell adhesion, and in the regulation of the production of cell surface antigens.

Given the unique combination of functions that SF3A2 has been shown to have, it is a promising target for drug development. Researchers are currently working to develop small molecules that can inhibit the activity of SF3A2 and enhance its stability in cells. These small molecules are being tested for their ability to treat a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

While the development of drugs that target SF3A2 is still in its early stages, it is clear that this protein has the potential to be a valuable drug target for a variety of diseases. Further research is needed to fully understand the functions of SF3A2 and to develop effective treatments for the various diseases that it is involved in.

Protein Name: Splicing Factor 3a Subunit 2

Functions: Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29361316, PubMed:29360106, PubMed:30315277). Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106)

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