Target Name: USP11
NCBI ID: G8237
Other Name(s): Ubiquitin-specific processing protease 11 | Ubiquitin thiolesterase 11 | deubiquitinating enzyme 11 | Ubiquitin-specific-processing protease 11 | UBP11_HUMAN | ubiquitin thioesterase 11 | UHX1 | Ubiquitin carboxyl-terminal hydrolase, X-linked | ubiquitin specific peptidase 11 | ubiquitin carboxyl-terminal hydrolase, X-linked | ubiquitin-specific processing protease 11 | Ubiquitin specific peptidase 11 | Ubiquitin carboxyl-terminal hydrolase 11 | ubiquitin thiolesterase 11 | Deubiquitinating enzyme 11 | Ubiquitin thioesterase 11

USP11: A Potential Drug Target and Biomarker for Ubiquitin-Specific Processing Protease 11

Ubiquitin (UV) is a protein that plays a critical role in the regulation of various cellular processes. It is a small molecule that functions as a linker, helping to connect one protein to another. There are several different forms of UV in the cell, each with its own unique function. One of these forms is Ubiquitin-specific processing protease 11 (USP11), which is a protein that is specific to Ubiquitin. USP11 is involved in the degradation of Ubiquitin, which is a ubiquitin protein that is often targeted for degradation by other proteins. This degradation is important for maintaining cellular homeostasis and for the regulation of various cellular processes.

The Importance of USP11 in Cellular Processes

USP11 is involved in the regulation of several cellular processes that are essential for cell survival. One of the processes that is regulated by USP11 is the degradation of Ubiquitin. Ubiquitin is a protein that plays a critical role in the regulation of various cellular processes, including cell division, cell signaling, and DNA replication. It is also involved in the regulation of inflammation and the immune response. Degradation of Ubiquitin is important for maintaining cellular homeostasis and for the regulation of these processes.

Another process that is regulated by USP11 is the regulation of protein stability. Ubiquitin is a protein that is involved in the regulation of protein stability, helping to ensure that proteins are stable and can perform their functions correctly. This regulation is important for the regulation of cellular processes such as cell signaling, DNA replication, and inflammation.

The Role of USP11 in Disease

The regulation of Ubiquitin by USP11 is also important for the regulation of diseases. Disruption of the Ubiquitin-specific processing protease 11 has been implicated in the development and progression of several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

One of the diseases that is associated with USP11 dysfunction is cancer. Cancer is a disease that is characterized by the uncontrolled growth and proliferation of cells. The regulation of Ubiquitin by USP11 is important for the regulation of cell growth and division. Disruption of this regulation has been implicated in the development and progression of cancer.

Another disease that is associated with USP11 dysfunction is neurodegenerative diseases. Neurodegenerative diseases are characterized by the progressive loss of brain cells and the development of various neurological symptoms. The regulation of Ubiquitin by USP11 is important for the regulation of the structure and function of nerve cells. Disruption of this regulation has been implicated in the development and progression of neurodegenerative diseases.

Another disease that is associated with USP11 dysfunction is autoimmune diseases. Autoimmune diseases are characterized by the immune system attacking the body's own tissues or organs. The regulation of Ubiquitin by USP11 is important for the regulation of the immune response. Disruption of this regulation has been implicated in the development and progression of autoimmune diseases.

Drug Targeting USP11

The regulation of Ubiquitin by USP11 is an attractive target for drug development. Drugs that can inhibit the activity of USP11 have been shown to have potential therapeutic benefits in a variety of diseases. One of the drugs that has been shown to be effective in inhibiting the activity of USP11 is Upsen

Protein Name: Ubiquitin Specific Peptidase 11

Functions: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:28992046, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Promotes cell proliferation by deubiquitinating phosphorylated E2F1 (PubMed:28992046)

More Common Targets

USP12 | USP12-AS1 | USP12-DT | USP13 | USP14 | USP15 | USP16 | USP17L1 | USP17L10 | USP17L11 | USP17L12 | USP17L13 | USP17L14P | USP17L15 | USP17L17 | USP17L18 | USP17L2 | USP17L20 | USP17L21 | USP17L24 | USP17L25 | USP17L26 | USP17L27 | USP17L29 | USP17L3 | USP17L5 | USP17L6P | USP17L7 | USP17L8 | USP17L9P | USP18 | USP19 | USP2 | USP2-AS1 | USP20 | USP21 | USP22 | USP24 | USP25 | USP26 | USP27X | USP27X-DT | USP28 | USP29 | USP3 | USP3-AS1 | USP30 | USP30-AS1 | USP31 | USP32 | USP32P1 | USP32P2 | USP32P3 | USP33 | USP34 | USP35 | USP36 | USP37 | USP38 | USP39 | USP4 | USP40 | USP41 | USP42 | USP43 | USP44 | USP45 | USP46 | USP46-DT | USP47 | USP48 | USP49 | USP5 | USP50 | USP51 | USP53 | USP54 | USP6 | USP6NL | USP6NL intronic transcript 1 (non-protein coding), transcript variant 1 | USP7 | USP8 | USP8P1 | USP9X | USP9Y | USPL1 | UST | UTF1 | UTP11 | UTP14A | UTP14C | UTP15 | UTP18 | UTP20 | UTP23 | UTP25 | UTP3 | UTP4 | UTP6 | UTRN