KLF11: A Protein Implicated in Immune Regulation and Disease (G8462)

Target Name: KLF11

NCBI ID: G8462

KLF11: A Protein Implicated in Immune Regulation and Disease

KLF11 (TIEG-2) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key regulator of the immune response and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its role in immune regulation, KLF11 has also been shown to play a key role in the development and progression of certain diseases. For example, studies have shown that KLF11 is overexpressed in the brains of individuals with Alzheimer's disease, and that it is involved in the development of certain neurodegenerative diseases.

KLF11 is also a potential drug target, and a number of studies are being conducted to investigate its potential as a therapeutic agent. For example, researchers have found that KLF11 can be targeted with small molecules and have shown that inhibiting its activity can protect against neurodegenerative diseases.

In addition to its potential as a drug target, KLF11 is also being investigated as a biomarker for certain diseases. For example, studies have shown that KLF11 levels can be used as a diagnostic marker for neurodegenerative diseases, and that they can be decreased in the brains of individuals with certain diseases.

Overall, KLF11 is a protein that has important roles in both immune regulation and disease development, and is an attractive target for further research and potential therapeutic intervention.

Protein Name: KLF Transcription Factor 11

Functions: Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity)

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