KISS1R: A Potential Drug Target and Biomarker (G84634)

Target Name: KISS1R

NCBI ID: G84634

KISS1R: A Potential Drug Target and Biomarker

KISS1R, also known as KIAA012053, is a gene that encodes a protein involved in the F-actinin-associated protein (FAP) signaling pathway. This pathway is a critical regulator of cell signaling, and dysregulation of FAP signaling has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Therefore, targeting FAP signaling pathway, including KISS1R, has the potential to lead to new therapeutic approaches for these diseases.

The F-actinin-associated protein (FAP) signaling pathway is a complex protein-protein interaction (PPI) signaling pathway that plays a crucial role in cell signaling. The FAP protein is a 21-kDa protein that is involved in the regulation of actinin, a protein that is essential for cell migration, invasion, and metastasis. The FAP protein is also involved in the regulation of various cellular processes, including cell adhesion, cell survival, and cell proliferation.

KISS1R, a gene encoding a protein involved in the FAP signaling pathway, has been identified as a potential drug target and biomarker for various diseases. KISS1R has been shown to be highly expressed in various tissues, including brain, heart, and pancreas, and has been associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key features of KISS1R is its involvement in the regulation of FAP signaling pathway. KISS1R has been shown to play a role in the regulation of FAP signaling by interacting with the FAP protein. This interaction between KISS1R and FAP has been shown to be critical for the regulation of various cellular processes, including cell adhesion, cell survival, and cell proliferation.

In addition to its involvement in FAP signaling, KISS1R has also been shown to be involved in the regulation of other signaling pathways, including the TGF-β pathway and the NF-kappa-B pathway. The TGF-β pathway is involved in the regulation of cell growth, differentiation, and survival, and has been implicated in various diseases, including cancer. The NF-kappa-B pathway is involved in the regulation of inflammation and immune responses, and has been implicated in various autoimmune diseases.

KISS1R has also been shown to be involved in the regulation of cellular processes that are important for cancer progression, including the regulation of cell apoptosis (programmed cell death), angiogenesis (the formation of new blood vessels), and invasion (the ability of cells to enter other tissues). Therefore, targeting KISS1R with drugs that can inhibit its function may be an effective way to treat various cancers.

In conclusion, KISS1R is a gene that encodes a protein involved in the F-actinin-associated protein (FAP) signaling pathway. This pathway is a critical regulator of cell signaling, and dysregulation of FAP signaling has been implicated in various diseases. Targeting FAP signaling pathway, including KISS1R, has the potential to lead to new therapeutic approaches for these diseases. Further research is needed to fully understand the role of KISS1R in cell signaling and its potential as a drug target and biomarker.

Protein Name: KISS1 Receptor

Functions: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins

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