Target Name: GGACT
NCBI ID: G87769
Other Name(s): Gamma-glutamylamine cyclotransferase, transcript variant 2 | Gamma-glutamylamine cyclotransferase, transcript variant X1 | GGACT variant X1 | Gamma-glutamylamine cyclotransferase | GGACT_HUMAN | Gamma-glutamylaminecyclotransferase | GGACT variant 2 | Gamma-glutamylaminecyclotransferase (isoform X1) | AIG2-like domain 1 | Gamma-glutamylamine cyclotransferase, transcript variant 1 | AIG2-like domain-containing protein 1 | gamma-glutamylamine cyclotransferase | A2LD1 | GGACT variant 1

GGACT: A Potential Drug Target for Psychiatric Disorders

Gamma-glutamylamine cyclotransferase (GGACT) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and heart. It is a key enzyme in the gamma-glutamyl cycle, a pathway that is involved in the metabolism of neurotransmitters, such as dopamine and serotonin. GGACT is also involved in the regulation of cellular signaling pathways, including the TGF-β pathway.

Recent studies have identified GGACT as a potential drug target for the treatment of various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression. This is because GGACT is involved in the synthesis of key neurotransmitters that are involved in the development and progression of these disorders. For example, GGACT has been shown to be involved in the production of amyloid, a protein that is thought to contribute to the development of Alzheimer's disease.

In addition to its role in neurotransmitter synthesis, GGACT is also involved in the regulation of cellular signaling pathways that are involved in the development and progression of various psychiatric and neurological disorders. For example, GGACT has been shown to be involved in the regulation of the activity of the transcription factor, NF-kappa-B, which is involved in the production of pro-inflammatory molecules that can contribute to the development of psychiatric disorders.

GGACT is also involved in the regulation of cellular signaling pathways that are involved in the development and progression of diseases that are characterized by inflammation and oxidative stress, such as heart disease and depression. For example, GGACT has been shown to be involved in the regulation of the activity of the transcription factor, NF-kappa-B, which is involved in the production of pro-inflammatory molecules that can contribute to the development of these diseases.

In conclusion, GGACT is a protein that is involved in a variety of cellular signaling pathways that are involved in the development and progression of various psychiatric and neurological disorders. As a result, GGACT is a potential drug target for the treatment of these disorders. Further research is needed to fully understand the role of GGACT in the development and progression of these disorders, as well as to develop effective treatments.

Protein Name: Gamma-glutamylamine Cyclotransferase

Functions: Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine

More Common Targets

GGCT | GGCX | GGH | GGN | GGNBP1 | GGNBP2 | GGPS1 | GGT1 | GGT2P | GGT3P | GGT5 | GGT6 | GGT7 | GGT8P | GGTA1 | GGTLC1 | GGTLC2 | GGTLC3 | GH1 | GH2 | GHDC | GHITM | GHR | GHRH | GHRHR | GHRL | GHRLOS | GHSR | GID4 | GID8 | GIGYF1 | GIGYF2 | GIHCG | GIMAP1 | GIMAP1-GIMAP5 | GIMAP2 | GIMAP3P | GIMAP4 | GIMAP5 | GIMAP6 | GIMAP7 | GIMAP8 | GIMD1 | GIN1 | GINM1 | GINS complex | GINS1 | GINS2 | GINS3 | GINS4 | GIP | GIPC1 | GIPC2 | GIPC3 | GIPR | GIT1 | GIT2 | GJA1 | GJA10 | GJA1P1 | GJA3 | GJA4 | GJA5 | GJA8 | GJA9 | GJA9-MYCBP | GJB1 | GJB2 | GJB3 | GJB4 | GJB5 | GJB6 | GJB7 | GJC1 | GJC2 | GJC3 | GJD2 | GJD3 | GJD4 | GK | GK2 | GK3 | GK5 | GKAP1 | GKN1 | GKN2 | GKN3P | GLA | GLB1 | GLB1L | GLB1L2 | GLB1L3 | GLC1C | GLCCI1 | GLCCI1-DT | GLCE | GLDC | GLDN | GLE1 | GLG1