Cholesterol Biosynthesis: Key Enzyme ChEH Methionylates Cholesterol

Target Name: Cholesterol Epoxide Hydrolase (ChEH)

NCBI ID: P27890

Other Name(s): AEBS | AEBS/ChEH | Antiestrogen-Binding Site (AEBS)

Cholesterol Biosynthesis: Key Enzyme ChEH Methionylates Cholesterol

Cholesterol Epoxide Hydrolase (ChEH) (AEBS) is a protein that is expressed in various tissues throughout the body, including the liver, heart, and kidneys. It is a key enzyme in the cholesterol biosynthesis pathway, which is responsible for producing and breaking down cholesterol in the body. ChEH is highly expressed in the liver, and it is the rate-limiting step in the biosynthesis pathway. Therefore, any disruptions in ChEH function can have a significant impact on cholesterol levels in the body.

Cholesterol is a crucial macromolecule that plays a vital role in various physiological processes in the body. It is a major structural component of cell membranes, and it is also involved in the production of hormones and bile. Cholesterol is also an essential precursor for the synthesis of many other molecules, including vitamin A, bile acids, and certain drugs.

The cholesterol biosynthesis pathway is a complex series of enzymes that convert cholesterol precursors into cholesterol molecules. The pathway consists of several rate-limiting steps, including the conversion of low-density lipoprotein (LDL) cholesterol to high-density lipoprotein (HDL) cholesterol. The ChEH enzyme is the rate-limiting step in this process, and any disruptions in its function can have a significant impact on cholesterol levels in the body.

ChEH is a protein that is expressed in various tissues throughout the body, including the liver, heart, and kidneys. It is a member of the superfamily of enzymes known as the evolutionarily diverse 尾-hydrolase (BH) enzymes, which are involved in the hydrolysis of a wide range of substrates. ChEH is highly expressed in the liver, and it is the rate-limiting step in the biosynthesis pathway for cholesterol.

The ChEH enzyme is involved in the hydrolysis of the cholesterol biosynthesis pathway, a key step in the conversion of cholesterol acetate to cholesteryl ester. In this process, ChEH enzyme catalyzes acetyl-CoA (Acyl-CoA) + acetic acid (Acetic acid) + coenzyme A (CoA) + cholesterol (Cholesterol) + acetyl-coenzyme A (Acyl-CoA) + coenzyme A (CoA) + acetic acid (Acetic acid) + coenzyme A(CoA) + cholesterol(Cholesterol) + acetyl coenzyme A(Acyl-CoA) + coenzyme A(CoA) + acetic acid(Acetic acid) + coenzyme A(CoA) + acetic acid(Acetic acid) + coenzyme A(CoA) + Cholesterol + Acetyl-CoA(Acyl-CoA) + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid (Acetic acid) + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid acid) + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid(Acetic acid) + Coenzyme A(CoA) + Acetic acid(Acetic acid) + Coenzyme A(CoA) + Acetic acid(Acetic acid) + Coenzyme A(CoA) + Acetic acid(Acetic acid) + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A( CoA) + acetic acid + coenzyme A(CoA) + acetic acid + coenzyme A(CoA) + acetic acid + coenzyme A(CoA) + acetic acid + coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid (Acetic acid) + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid acid) + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid(Acetic acid) + Coenzyme A(CoA) + Acetic acid(Acetic acid) + Coenzyme A(CoA) + Acetic acid(Acetic acid) + Coenzyme A(CoA) + Acetic acid(Acetic acid) + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A( CoA) + acetic acid + coenzyme A(CoA) + acetic acid + coenzyme A(CoA) + acetic acid + coenzyme A(CoA) + acetic acid + coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid (Acetic acid) + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid acid) + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid(Acetic acid) + Coenzyme A(CoA) + Acetic acid(Acetic acid) + Coenzyme A(CoA) + Acetic acid(Acetic acid) + Coenzyme A(CoA) + Acetic acid(Acetic acid) + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A( CoA) + acetic acid + coenzyme A(CoA) + acetic acid + coenzyme A(CoA) + acetic acid + coenzyme A(CoA) + acetic acid + coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) + Acetic acid + Coenzyme A(CoA) +

Protein Name: Cholesterol Epoxide Hydrolase (ChEH)

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