Alpha Subunit: Key Component of DNA Polynucleotide Synthesis (P38207)

Target Name: DNA Polymerase zeta Complex

NCBI ID: P38207

Other Name(s): None

Alpha Subunit: Key Component of DNA Polynucleotide Synthesis

DNA polymerase zeta complex is a protein that plays a critical role in the replication of DNA in eukaryotic cells. It is a complex enzyme that consists of multiple subunits that work together to ensure the proper functioning of DNA replication. One of the subunits of the DNA polymerase zeta complex is the alpha subunit, which is a key component of the enzyme and is responsible for catalyzing the polymerization of DNA.

The alpha subunit of the DNA polymerase zeta complex is a protein that contains a unique structure that allows it to interact with DNA in a specific way. This interaction is important for the proper functioning of the enzyme and is the target of many researchers as a potential drug target.

One of the key features of the alpha subunit is its ability to form a stable complex with the double helix. This complex is formed through a process called co-factor recruitment, during which the alpha subunit binds to the Richardson factor and the thymidine kinase. This interaction allows the alpha subunit to efficiently catalyze the polymerization of DNA and ensures that the new strand is synthesized accurately onto the template.

Another unique feature of the alpha subunit is its ability to inhibit the activity of other DNA polymerase enzymes. This inhibition is important for controlling the efficiency of DNA replication and is a potential target for drugs that aim to inhibit the replication of cancer cells.

The alpha subunit of the DNA polymerase zeta complex is also known for its role in the regulation of DNA replication. It is able to interact with the double helix and can inhibit the activity of other DNA polymerase enzymes, which allows it to control the speed at which DNA is replicated. This regulation is important for ensuring that the cell has enough DNA to support its growth and functions properly.

In addition to its role in DNA replication, the alpha subunit of the DNA polymerase zeta complex is also involved in the regulation of gene expression. It is able to interact with the RNA polymerase and can regulate the amount of RNA produced from a given DNA template . This regulation is important for ensuring that the cell has the right amount of RNA to support its gene expression.

Overall, the alpha subunit of the DNA polymerase zeta complex is a unique and important protein that plays a critical role in the replication of DNA in eukaryotic cells. Its ability to form a stable complex with DNA and its ability to inhibit the activity of other DNA polymerase enzymes make it an attractive target for drugs that aim to inhibit the replication of cancer cells or diseases. Furthermore, its role in regulating DNA replication and gene expression makes it a potential biomarker for a variety of diseases.

Protein Name: DNA Polymerase Zeta Complex

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