Study on GPR45: Potential Drug Target and Biomarker (G11250)

Target Name: GPR45

NCBI ID: G11250

Study on GPR45: Potential Drug Target and Biomarker

GPR45 (G protein-coupled receptor 45) is a G protein-coupled receptor that is expressed in various tissues and cells in the body. It is a member of the GPR family, which is a large superfamily of transmembrane proteins that play a crucial role in cellular signaling. GPR45 is one of the most well-studied GPRs, and a significant amount of research has focused on its potential as a drug target or biomarker.

GPR45 is a 19-kDa protein that is expressed in the brain, heart, kidneys, and other tissues. It is highly conserved, with a calculated pI of 12.9 and a predicted transmembrane potential of 200 mV. GPR45 has four transmembrane domains, which are involved in its signaling function. The first transmembrane domain is a N-terminal alpha-helices that is involved in the formation of the extracellular domain. The second transmembrane domain is a Z-terminal alpha-helices that is involved in the formation of the intracellular domain. The third transmembrane domain is a V-terminal alpha-helices that is involved in the formation of the intracellular domain. The fourth transmembrane domain is a C-terminal alpha-helices that is involved in the formation of the intracellular domain.

GPR45 has been shown to play a role in a variety of physiological processes, including pain perception, inflammation, and neurodegeneration. GPR45 is involved in the delivery of pain signals from the central nervous system to the brain, and has been shown to play a role in the regulation of pain modulation. GPR45 is also involved in the regulation of inflammation, and has been shown to play a role in the regulation of inflammation-induced pain. GPR45 is also involved in the regulation of neurodegeneration, and has been shown to play a role in the development of neurodegenerative diseases.

GPR45 has also been shown to be a potential drug target, and is being targeted by a variety of drug developers. GPR45 has been shown to be involved in the regulation of a variety of physiological processes, including pain perception, inflammation, and neurodegeneration. GPR45 has also been shown to play a role in the delivery of pain signals from the central nervous system to the brain, and has been shown to be involved in the regulation of pain modulation. GPR45 is also involved in the regulation of inflammation, and has been shown to play a role in the regulation of inflammation-induced pain. GPR45 is also involved in the regulation of neurodegeneration, and has been shown to play a role in the development of neurodegenerative diseases.

In conclusion, GPR45 is a G protein-coupled receptor that is highly conserved and expressed in various tissues and cells in the body. It is involved in a variety of physiological processes, including pain perception, inflammation, and neurodegeneration. GPR45 has also been shown to be a potential drug target, and is being targeted by a variety of drug developers. Further research is needed to fully understand the role of GPR45 in these processes and its potential as a drug.

Protein Name: G Protein-coupled Receptor 45

Functions: Orphan receptor. May play a role in brain function

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