Understanding The Role of ETFA Alpha-Subunit in Cellular Processes

Target Name: ETFA

NCBI ID: G2108

Understanding The Role of ETFA Alpha-Subunit in Cellular Processes

Electron transfer flavoprotein (ETF) alpha-subunit, also known as ETFA, is a protein that plays a crucial role in the electron transport chain of photosynthetic organisms. Recently, ETFA has been identified as a potential drug target and a biomarker for several diseases, including cancer, neurodegenerative diseases, and respiratory disorders.

The ETFA protein is a subunit of the well-known protein Photosystem II, which is responsible for capturing and transferring electrons to the photosynthetic active site of chlorophyll. The ETFA subunit is composed of 21 amino acid residues and has a calculated molecular weight of 34 kDa.

Recent studies have shown that ETFA is involved in various cellular processes, including photosynthesis, electron transport, and cell signaling. One of the most significant functions of ETFA is its role in the electron transport chain. This subunit is responsible for transferring electrons from the cytosol to the photosynthetic active site, where they are used to produce ATP and NADPH, which are essential for the production of energy by photosynthesis.

In addition to its role in the electron transport chain, ETFA is also involved in several other cellular processes. For example, it has been shown to play a role in cell signaling, specifically in the regulation of cell growth and differentiation. Additionally, ETFA has been shown to be involved in the regulation of protein folding and stability, as well as in the modulation of gene expression.

The potential drug target status of ETFA is due to several factors. Firstly, ETFA is a protein that has been identified as a potential drug target for several diseases, including cancer, neurodegenerative diseases, and respiratory disorders. Secondly, ETFA has been shown to play a role in the regulation of essential cellular processes, which makes it an attractive target for drugs that aim to modulate these processes. Finally, the functional characterization of ETFA as a potential drug or biomarker has been supported by several in vitro and in vivo studies.

In conclusion, ETFA alpha-subunit is a protein that has a significant impact on various cellular processes, including photosynthesis, electron transport, and cell signaling. Its potential as a drug target or biomarker makes it an attractive target for the development of new therapeutic agents for a variety of diseases. Further research is needed to fully understand the role of ETFA in these processes and to develop effective strategies for its targeting and manipulation.

Protein Name: Electron Transfer Flavoprotein Subunit Alpha

Functions: Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:27499296, PubMed:15159392, PubMed:15975918, PubMed:9334218, PubMed:10356313). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1882842, PubMed:1430199)

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