SCUBE3: A Potential Drug Target and Biomarker (G222663)

Target Name: SCUBE3

NCBI ID: G222663

SCUBE3: A Potential Drug Target and Biomarker

Signal peptide, CUB domain and EGF-like domain containing 3 (SCUBE3) is a protein that has been identified as a potential drug target and biomarker. SCUBE3 is a member of the SCUBE family, which includes four structurally similar genes that are involved in the regulation of cell adhesion and signaling pathways. The SCUBE genes encode for small non-cysteine-containing transmembrane proteins that contain a signal peptide, a CUB domain, and an EGF-like domain.

The SCUBE3 protein is composed of 114 amino acid residues and has a calculated molecular mass of 13.9 kDa. It has a characteristic signal peptide that is involved in the formation of the protein and is thought to play a role in the protein's intracellular localization and stability. The CUB domain is a conserved region that is involved in the formation of tight complexions between the protein and other ligands, while the EGF-like domain is a conserved region that is involved in the regulation of protein function.

SCUBE3 has been shown to play a role in several cellular processes, including cell adhesion, migration, and invasion. For example, studies have shown that SCUBE3 is involved in the regulation of tight junction formation and that it plays a role in the development of cancer . Additionally, SCUBE3 has been shown to be involved in the regulation of neurotransmitter signaling pathways and has been implicated in the development of neurodegenerative diseases.

Given the potential role of SCUBE3 in several cellular processes, it is a promising target for drug development. Studies have shown that SCUBE3 can be targeted with small molecules and that these treatments can inhibit the activity of SCUBE3 and its downstream targets. Additionally, cell- Based assays have shown that inhibition of SCUBE3 can lead to the disruption of several cellular processes, including cell adhesion, migration, and invasion.

In conclusion, SCUBE3 is a protein that has been identified as a potential drug target and biomarker. Its structure and function have been well-studied and its potential as a drug target is supported by both in vitro and in vivo studies. Further research is needed to fully understand the role of SCUBE3 in cellular processes and to develop effective treatments.

Protein Name: Signal Peptide, CUB Domain And EGF Like Domain Containing 3

Functions: Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development. It acts as coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors (PubMed:33308444). It is required for ligand-induced recruitment of BMP receptors to lipid rafts (By similarity). Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression

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