KIFC1: A Protein with Potential as A Drug Target (G3833)

Target Name: KIFC1

NCBI ID: G3833

KIFC1: A Protein with Potential as A Drug Target

Kinesin-like protein 2 (KIFC1) is a protein that is expressed in various tissues throughout the body, including muscle, heart, and brain. It is characterized by its ability to catalyze the transfer of genetic material from the microtubules of the eukaryotic mitochondria to the cytoplasm. This protein plays a crucial role in the process of mitochondrial inheritance and has been implicated in a number of cellular processes, including the regulation of mitochondrial dynamics, protein folding, and stress responses.

KIFC1 is a member of the Kinesin-like protein family, which includes a number of related proteins that share a conserved catalytic core and structural features. These proteins are characterized by their ability to form a covalent complex with nucleotides, which they then use to move along the cytoskeleton and perform a variety of cellular functions.

One of the unique features of KIFC1 is its ability to form a stable and reversible complex with nucleotides. This allows the protein to act as a highly efficient carrier of genetic material, allowing it to be easily targeted by small molecules and to participate in a wide range of cellular processes. Additionally, KIFC1's ability to form a stable complex with nucleotides makes it a promising target for the development of new drugs that can inhibit its activity.

In addition to its role in cellular processes, KIFC1 is also of interest as a potential drug target. Its ability to carry genetic material through the cytoskeleton and its involvement in the regulation of mitochondrial dynamics make it an attractive target for the development of drugs that can modulate these processes. Additionally, KIFC1's stability and reversibility in its nucleotide binding properties make it a promising target for drugs that can inhibit its activity and improve the efficacy of existing treatments.

Overall, KIFC1 is a protein that has significant potential as a drug target or biomarker. Its unique ability to form a stable and reversible complex with nucleotides and its involvement in cellular processes make it an attractive target for the development of new treatments. Further research is needed to fully understand the mechanisms of KIFC1's activity and its potential as a drug.

Protein Name: Kinesin Family Member C1

Functions: Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity)

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