KIRREL3: A Potential Drug Target for Insulin Sensitivity and Neurodegeneration

Target Name: KIRREL3

NCBI ID: G84623

KIRREL3: A Potential Drug Target for Insulin Sensitivity and Neurodegeneration

KIRREL3 (K-type insulin receptor alpha chain, KIRREL3) is a protein that is expressed in various tissues and cells in the body. It is a member of the insulin receptor family, which is a critical protein that plays a crucial role in the regulation of glucose metabolism. KIRREL3 is highly conserved and has a similar structure to other members of the insulin receptor family.

The insulin receptor is a transmembrane protein that is composed of an extracellular portion and an intracellular portion. The extracellular portion of the insulin receptor is involved in the regulation of cell surface proteins, while the intracellular portion is involved in the regulation of intracellular signaling pathways. The insulin receptor is composed of two transmembrane subunits, which are held together by ionic bonds.

KIRREL3 is a 120-kDa protein that is expressed in various tissues and cells, including muscle, fat, and brain. It is highly conserved and has a similar structure to other members of the insulin receptor family. KIRREL3 has a unique N-terminus that is distinct from other members of the insulin receptor family.

KIRREL3 is involved in the regulation of glucose metabolism by playing a role in the intracellular signaling pathway that is responsible for the regulation of insulin sensitivity. Insulin sensitivity is the ability of cells to respond to insulin, and is an important factor in the regulation of glucose metabolism.

KIRREL3 is involved in the regulation of several intracellular signaling pathways, including the TGF-beta pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. These pathways are involved in the regulation of cell growth, differentiation, and inflammation.

KIRREL3 is also involved in the regulation of cellular signaling pathways that are involved in the regulation of pain perception and neurodegeneration. For example, KIRREL3 is involved in the regulation of the release of endogenous opioids, which are involved in the regulation of pain perception. KIRREL3 is also involved in the regulation of the release of neurotransmitters, such as serotonin, which is involved in the regulation of mood and anxiety.

KIRREL3 is a potential drug target and may be useful for the treatment of various diseases. For example, KIRREL3 may be useful for the treatment of obesity, as it is involved in the regulation of insulin sensitivity and the regulation of cellular signaling pathways that are involved in the regulation of appetite and energy expenditure. KIRREL3 may also be useful for the treatment of diabetes, as it is involved in the regulation of insulin sensitivity and the regulation of cellular signaling pathways that are involved in the regulation of glucose metabolism.

In conclusion, KIRREL3 is a protein that is involved in the regulation of insulin sensitivity and the regulation of cellular signaling pathways that are involved in the regulation of pain perception and neurodegeneration. It may be a potential drug target and may be useful for the treatment of various diseases. Further research is needed to fully understand the role of KIRREL3 in the regulation of insulin sensitivity and cellular signaling pathways.

Protein Name: Kirre Like Nephrin Family Adhesion Molecule 3

Functions: Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells

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