MSLNL: A Potential Drug Target and Biomarker for Mesothelin (G401827)

Target Name: MSLNL

NCBI ID: G401827

Other Name(s): Mesothelin-like | mesothelin like | MPFL | C16orf37

MSLNL: A Potential Drug Target and Biomarker for Mesothelin

Mesothelin is a transmembrane protein that is highly expressed in various tissues, including cancer cells, and plays a crucial role in cell signaling, adhesion, and survival. However, despite its importance, the regulation of mesothelin has remained a challenge throughout the years. Mesothelin has been associated with various diseases, including cancer, and has been identified as a potential drug target. In this article, we will explore the MSLNL protein, which is similar to mesothelin, as a potential drug target and biomarker for mesothelin.

The MSLNL Protein

MSLNL (Mesothelin-like like) is a transmembrane protein that is characterized by the presence of a N-terminal extracellular domain, a transmembrane region, and an C-terminal intracellular domain. It has a molecular weight of approximately 21 kDa and is expressed in various tissues, including cancer cells. MSLNL is highly homophilic with mesothelin, and its amino acid sequence is similar to that of mesothelin.

The MSLNL protein is involved in various cellular processes, including cell signaling, adhesion, and survival. It has been shown to be involved in several signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. MSLNL has also been shown to play a role in cell adhesion, as it is involved in the formation of tight junctions and adherens junctions, which are essential for cell-cell and cell-extracellular matrix adhesion.

In addition to its role in cell signaling and adhesion, MSLNL has also been shown to play a role in cell survival. It has been shown to be involved in the regulation of cell apoptosis, as well as cell cycle progression.

The MSLNL-Mesothelin Complex

The MSLNL protein can form a complex with mesothelin, which is a transmembrane protein that is also involved in cell signaling and adhesion. The MSLNL-Mesothelin complex plays a role in regulating cell signaling and adhesion, as well as cell survival.

The MSLNL-Mesothelin complex functions as a receptor for several signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. It has been shown that the MSLNL-Mesothelin complex plays a role in the regulation of cell proliferation, cell apoptosis, and cell migration.

The MSLNL-Mesothelin Complex as a Drug Target

The MSLNL-Mesothelin complex is a potential drug target for mesothelin-related diseases. Several studies have shown that inhibiting the MSLNL-Mesothelin complex can lead to the downregulation of mesothelin, which can lead to the loss of cell signaling and adhesion.

One of the potential strategies for targeting the MSLNL-Mesothelin complex is the use of small molecules that can inhibit the interaction between MSLNL and mesothelin. Several studies have shown that inhibitors of the MSLNL-Mesothelin complex, such as FAK inhibitors, can lead to the downregulation of mesothelin and the loss of cell signaling and adhesion.

Another strategy for targeting the MSLNL-Mesothelin complex is the use of antibodies that can specifically recognize and target the MSLNL protein. Several studies have shown that antibodies that recognize the MSLNL protein can lead to the inhibition of the MSLNL-Mesothelin complex and the loss of cell signaling and adhesion.

The MSLNL-Mesothelin Complex as a Biomarker

MSLNL is also a potential biomarker for mesothelin-related diseases. The MSLNL-Mesothelin complex can be used as a biomarker for the detection and evaluation of

Protein Name: Mesothelin Like

Functions: May play a role in cellular adhesion

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