MTDH: A Protein Involved in Immune Response and Disease (G92140)

Target Name: MTDH

NCBI ID: G92140

MTDH: A Protein Involved in Immune Response and Disease

MTDH (3D3/lyric) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a key regulator of the immune response and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the unique features of MTDH is its ability to self-cleave, meaning that it can break down into smaller pieces on its own and be eliminated from the body. This property makes it an attractive target for researchers looking for new drugs or biomarkers.

In addition to its potential as a drug or biomarker, MTDH is also of interest to researchers studying the immune system and its role in disease. The immune system is a critical component of the body's defenses against infection and disease, and MTDH has been shown to play a role in regulating the immune response.

One of the key functions of MTDH is its role in the regulation of T cell development and function. T cells are a type of immune cell that play a critical role in protecting the body against infection and disease. They are generated from stem cells in the bone marrow and are responsible for producing a variety of different immune cells, including T cells, B cells, and natural killer cells.

MTDH has been shown to play a key role in regulating T cell development and function. It has been shown to promote the development and survival of T cells, as well as the production of antibodies by T cells. This is important because T cells are a critical component of the immune system and play a key role in protecting the body against infection and disease.

Another function of MTDH is its role in the regulation of inflammation. Inflammation is a natural response of the immune system to injury or infection, and it can be a sign of an underlying disease. MTDH has been shown to play a key role in regulating the production of pro-inflammatory cytokines, which are important drivers of inflammation.

This is important because chronic inflammation can contribute to a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. By targeting MTDH, researchers may be able to develop new treatments for these diseases.

In addition to its potential as a drug or biomarker, MTDH is also of interest to researchers studying the role of the immune system in disease. MTDH has been shown to play a key role in regulating the production of antibodies, which are important proteins produced by the immune system in response to the presence of foreign particles in the body.

Targeting MTDH may also be a promising approach to treating some types of cancer. Some studies have shown that MTDH may be expressed in different types of cancer cells, including breast, ovarian, and prostate cancer cells. This suggests that targeting MTDH in cancer cells may be a promising approach to treating these diseases.

In conclusion, MTDH is a protein that is expressed in various tissues of the body and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its ability to self-cleave and its role in regulating the immune system and inflammation make it an attractive target for researchers looking for new drugs or biomarkers. Further studies are needed to fully understand the role of MTDH in disease and to develop effective treatments.

Protein Name: Metadherin

Functions: Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance

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