MTHFD2L: A Potential Drug Target and Biomarker (G441024)

Target Name: MTHFD2L

NCBI ID: G441024

Other Name(s): MGC72244 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like | MTHFD2L variant X11 | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 | NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | MTD2L_HUMAN | OTTHUMP00000211524 | OTTHUMP00000211520 | MGC45532 | tetrahydrofolate dehydrogenase/cyclohydrolase | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial; probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, transcript variant X11 | MTHFD2L variant 2 | Tetrahydrofolate dehydrogenase/cyclohydrolase | Methenyltetrahydrofolate cyclohydrolase | MTHFD2-like | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like, transcript variant 2 | probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 | NAD-dependent methylenetetrahydrofolate dehydrogenase | FLJ13105 | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform 2 | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X8

MTHFD2L: A Potential Drug Target and Biomarker

MTHFD2L, or meta-theta-hydroxy-flavin-2-deficient, is a gene that encodes a protein known as MTHFD2L. The MTHFD2L protein is a member of the superfamily of flavin proteins, which are a type of transmembrane protein that plays a crucial role in a variety of cellular processes, including energy metabolism, signaling, and response to environmental stimuli.

MTHFD2L is unique among its kind, as it is the only known protein that contains a meta-theta motif. The meta-theta motif is a specific type of hydrogen bonding that is found in proteins that are involved in various cellular processes, including metabolism, signaling, and response to environmental stimuli. The presence of a meta-theta motif in MTHFD2L has implications for its function and potential as a drug target.

MTHFD2L is expressed in various tissues and cells throughout the body, including the liver, muscle, heart, and pancreas. It is also expressed in various types of cancer, which suggests that it may be a potential drug target for cancer therapies. Additionally, MTHFD2L is a potent inhibitor of the enzyme farnesyl-protein synthesizing (FPS), which is involved in the production of fatty acids and other molecules that are essential for cellular growth and maintenance.

The potential drug targets for MTHFD2L are vast and varied. One of the most promising targets is the inhibition of FPS, which would result in reduced production of fatty acids and potential therapeutic benefits for diseases that are characterized by uncontrolled fatty acid storage, such as cancer, obesity, and Alzheimer's disease. Additionally, MTHFD2L has been shown to be involved in cellular signaling pathways, which suggests that it may be a potential target for drugs that are used to modulate cellular signaling pathways.

Another potential drug target for MTHFD2L is its role in energy metabolism. MTHFD2L is involved in the production of ATP, which is the energy currency of the cell. It is also involved in the metabolism of glucose and fatty acids, which are critical for cellular energy The inhibition of MTHFD2L activity in these areas could lead to reduced ATP production and potential therapeutic benefits for diseases that are characterized by energy metabolism disorders, such as cancer, diabetes, and obesity.

In conclusion, MTHFD2L is a unique and promising protein that has implications for a variety of cellular processes. Its unique meta-theta motif, its involvement in energy metabolism, and its potential as a drug target make it an attractive target for further research and development . Further studies are needed to fully understand the function and potential of MTHFD2L, and to determine its effectiveness as a drug.

Protein Name: Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2 Like

Functions: Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities

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