MSR1: A Protein Involved in Phagocytosis, Inflammation and Immune Response

Target Name: MSR1

NCBI ID: G4481

MSR1: A Protein Involved in Phagocytosis, Inflammation and Immune Response

MSR1 (Macrophage scavenger receptor 1, transcript variant SR-AIII) is a protein that is expressed in various tissues of the body, including the brain, spleen, heart, and lungs. It is a member of the MSR family of transmembrane proteins, which are involved in the process of phagocytosis, the process by which white blood cells engulf and destroy foreign particles in the body.

MSR1 is involved in the recruitment of phagocytosis-associated molecular components (PAMCs) to the site of inflammation or infection. These PAMCs include various types of white blood cells, such as neutrophils and macrophages, which are crucial for protecting the body against infection and inflammation.

One of the unique features of MSR1 is its ability to interact with several different types of PAMCs. This allows it to play a critical role in the recruitment of these cells to the site of inflammation or infection, and in the regulation of their movement and behavior.

MSR1 has also been shown to play a key role in the regulation of inflammation and immune response. It has been shown to interact with various cytokines and chemokines, which are involved in the regulation of inflammation and immune cell function.

In addition to its role in inflammation and immune response, MSR1 has also been shown to be involved in the regulation of cell survival and metabolism. This is because of its ability to interact with various cellular signaling pathways, including the PI3K/Akt signaling pathway, which is involved in the regulation of cell survival and metabolism.

Given its involvement in a wide range of physiological processes, MSR1 has been identified as a potential drug target. Researchers are currently working to develop small molecules that can inhibit the activity of MSR1 and enhance its function as a drug target.

In addition to its potential as a drug target, MSR1 has also been shown to be a potential biomarker. The expression of MSR1 has been shown to be associated with a number of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Given its potential as a drug target and biomarker, MSR1 is an attractive target for research into the treatment of a wide range of diseases.

Overall, MSR1 is a protein that is involved in a wide range of physiological processes and has been shown to play a critical role in the regulation of inflammation and immune response. As a potential drug target and biomarker, its study is of great interest and will have a significant impact on our understanding of these processes and their role in the development of various diseases.

Protein Name: Macrophage Scavenger Receptor 1

Functions: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform III does not internalize acetylated LDL (PubMed:9548586)

More Common Targets